US2002020111 NEUROPROTECTION AND/OR NEURORESTORATION VIA THE NEURAL AVTIVIN TYPE IIB RECEPTOR

1. (WO2003000281) NEUROPROTECTION AND/OR NEURORESTORATION VIA THE NEURAL AVTIVIN TYPE IIB RECEPTOR

Notices

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Latest bibliographic data on file with the International Bureau

Pub. No.:	WO/2003/000281	International Application No.:	PCT/US2002/020111
Publication Date:	03.01.2003	International Filing Date:	21.06.2002
Chapter 2 Demand Filed:	17.01.2003

IPC:

A61K 31/395 (2006.01), A61K 31/44 (2006.01), A61K 31/445 (2006.01), A61K 31/565 (2006.01), A61K 38/18 (2006.01), A61K 38/19 (2006.01), A61K 38/20 (2006.01), A61K 38/24 (2006.01), A61K 38/49 (2006.01)

Applicants:

NEURONZ LIMITED [NZ/NZ]; Level 3, 2-6 Park Avenue, Grafton, Auckland (NZ).
FREYBERG, Derek, P. [US/US]; (US) (MZ only)

Inventors:

HUGHES, Paul, E.; (NZ).
FERNANDEZ, John, Anthony, Cajetan; (NZ).
RANIGA, Sumit; (NZ)

Agent:

MEYER, Sheldon, R.; Fliesler Dubb Meyer & Lovejoy LLP, Four Embarcadero Center, Suite 400, San Francisco, CA 94111-4156 (US)

Priority Data:

60/300,514

22.06.2001

Title

(EN) NEUROPROTECTION AND/OR NEURORESTORATION VIA THE NEURAL AVTIVIN TYPE IIB RECEPTOR
(FR) NEUROPROTECTION ET/OU NEURORESTORATION VIA LE RECEPTEUR DE L'ACTIVINE NEURALE DE TYPE IIB

Abstract:

(EN)The neural Type IIB activin receptor (ActRIIB) is strongly expressed in the injured brain, in contrast to the near absence of its expression in the uninjured, non-diseased brain. This invention is directed to the use of ActRIIB activating agents and disinhibiting agents in treating neuronal insult (including stroke). This invention provides agents and methods of using agents that activate or disinhibit ActRIIB, and associated intracellular signaling pathways, as neuroprotective and neurorestorative agents that are specifically targeted to the injured brain and selectively to injured regions of the brain.
(FR)L'invention concerne un récepteur de l'activine neurale de type IIB (ActRIIB) fortement exprimé dans un cerveau blessé alors qu'il ne l'est et pratiquement pas dans un cerveau non blessé, non malade. L'invention concerne également l'utilisation d'agents d'activation et de disinhibition de ActRIIB pour traiter une agression neuronale (notamment un accident cérébrovasculaire). L'invention concerne des agents et de méthodes utilisant lesdits agents pour activer ou disinhiber ActRIIB, et des chemins de signalisation intracellulaires associés utilisés comme agents neuroprotecteurs et neurorestorateurs ciblant spécifiquement le cerveau blessé et sélectivement des régions blessées du cerveau.

Designated States:

AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).

Publication Language:	English (EN)
Filing Language:	English (EN)

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