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Machine translation
1. (WO2003000281) NEUROPROTECTION AND/OR NEURORESTORATION VIA THE NEURAL AVTIVIN TYPE IIB RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/000281    International Application No.:    PCT/US2002/020111
Publication Date: 03.01.2003 International Filing Date: 21.06.2002
Chapter 2 Demand Filed:    17.01.2003    
IPC:
A61K 31/395 (2006.01), A61K 31/44 (2006.01), A61K 31/445 (2006.01), A61K 31/565 (2006.01), A61K 38/18 (2006.01), A61K 38/19 (2006.01), A61K 38/20 (2006.01), A61K 38/24 (2006.01), A61K 38/49 (2006.01)
Applicants: NEURONZ LIMITED [NZ/NZ]; Level 3, 2-6 Park Avenue, Grafton, Auckland (NZ).
FREYBERG, Derek, P. [US/US]; (US) (MZ only)
Inventors: HUGHES, Paul, E.; (NZ).
FERNANDEZ, John, Anthony, Cajetan; (NZ).
RANIGA, Sumit; (NZ)
Agent: MEYER, Sheldon, R.; Fliesler Dubb Meyer & Lovejoy LLP, Four Embarcadero Center, Suite 400, San Francisco, CA 94111-4156 (US)
Priority Data:
60/300,514 22.06.2001 US
Title (EN) NEUROPROTECTION AND/OR NEURORESTORATION VIA THE NEURAL AVTIVIN TYPE IIB RECEPTOR
(FR) NEUROPROTECTION ET/OU NEURORESTORATION VIA LE RECEPTEUR DE L'ACTIVINE NEURALE DE TYPE IIB
Abstract: front page image
(EN)The neural Type IIB activin receptor (ActRIIB) is strongly expressed in the injured brain, in contrast to the near absence of its expression in the uninjured, non-diseased brain. This invention is directed to the use of ActRIIB activating agents and disinhibiting agents in treating neuronal insult (including stroke). This invention provides agents and methods of using agents that activate or disinhibit ActRIIB, and associated intracellular signaling pathways, as neuroprotective and neurorestorative agents that are specifically targeted to the injured brain and selectively to injured regions of the brain.
(FR)L'invention concerne un récepteur de l'activine neurale de type IIB (ActRIIB) fortement exprimé dans un cerveau blessé alors qu'il ne l'est et pratiquement pas dans un cerveau non blessé, non malade. L'invention concerne également l'utilisation d'agents d'activation et de disinhibition de ActRIIB pour traiter une agression neuronale (notamment un accident cérébrovasculaire). L'invention concerne des agents et de méthodes utilisant lesdits agents pour activer ou disinhiber ActRIIB, et des chemins de signalisation intracellulaires associés utilisés comme agents neuroprotecteurs et neurorestorateurs ciblant spécifiquement le cerveau blessé et sélectivement des régions blessées du cerveau.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)