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1. WO2003000200 - $g(b)-2'-OR 3'-HALONUCLEOSIDES

Publication Number WO/2003/000200
Publication Date 03.01.2003
International Application No. PCT/US2002/020245
International Filing Date 24.06.2002
Chapter 2 Demand Filed 09.01.2003
IPC
C07H 9/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
9Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
02the hetero ring containing only oxygen as ring hetero atoms
04Cyclic acetals
C07H 19/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
CPC
A61K 31/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
A61K 31/522
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
522having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61K 31/675
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 31/70
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
A61K 31/7064
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
A61K 31/7084
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
Applicants
  • PHARMASSET LTD. [BB]/[BB] (AllExceptUS)
  • UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US]/[US] (AllExceptUS)
  • EMORY UNIVERSITY [US]/[US] (AllExceptUS)
  • CHU, Chung, K. [US]/[US] (UsOnly)
  • OTTO, Michael, J. [US]/[US] (UsOnly)
  • SHI, Junxing [CN]/[US] (UsOnly)
  • SCHINAZI, Raymond, F. [US]/[US] (UsOnly)
  • CHOI, Yongseok [KR]/[US] (UsOnly)
  • GUMINA, Giuseppe [IT]/[US] (UsOnly)
  • CHONG, Youhoon [KR]/[US] (UsOnly)
  • STUYVER, Lieven, J. [BE]/[US] (UsOnly)
Inventors
  • CHU, Chung, K.
  • OTTO, Michael, J.
  • SHI, Junxing
  • SCHINAZI, Raymond, F.
  • CHOI, Yongseok
  • GUMINA, Giuseppe
  • CHONG, Youhoon
  • STUYVER, Lieven, J.
Agents
  • KNOWLES, Sherry, M.
Priority Data
60/300,35622.06.2001US
60/305,38613.07.2001US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) $g(b)-2'-OR 3'-HALONUCLEOSIDES
(FR) ß-2'-OU 3'-HALONUCLEOSIDES
Abstract
(EN) The present invention includes compounds and compositions of $g(b)-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or compositions.
(FR) L'invention concerne des composés et des compositions de ß-halonucléosides, ainsi que des procédés de traitement du VIH, du virus de l'hépatite B ou de la prolifération cellulaire anormale qui consistent à administrer lesdits composés ou lesdites compositions.
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