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Machine translation
1. (WO2003000179) CHEMICALLY-MODIFIED PROGENIPOIETIN CONJUGATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/000179    International Application No.:    PCT/US2002/018810
Publication Date: 03.01.2003 International Filing Date: 14.06.2002
Chapter 2 Demand Filed:    21.01.2003    
IPC:
A61K 38/20 (2006.01), A61K 47/48 (2006.01), C12N 5/06 (2006.01)
Applicants: PHARMACIA CORPORATION [US/US]; 100 Route 206 North Peapack, NJ 07977 (US) (For All Designated States Except US).
SIEGEL, Ned, R. [US/US]; (US) (For US Only).
FINN, Rory, F. [US/US]; (US) (For US Only).
HILLS, Robert, L. [US/US]; (US) (For US Only)
Inventors: SIEGEL, Ned, R.; (US).
FINN, Rory, F.; (US).
HILLS, Robert, L.; (US)
Agent: NIELSEN, Carol, M.; Gardere Wynne Sewell LLP, Patent Section (H), 1601 Elm Street, Suite 3000, Dallas, TX 75201-4761 (US)
Priority Data:
60/300,362 22.06.2001 US
Title (EN) CHEMICALLY-MODIFIED PROGENIPOIETIN CONJUGATES
(FR) CONJUGUES DE PROTEINE « PROGENIPOIETIN » CHIMIQUEMENT MODIFIES
Abstract: front page image
(EN)The present invention provides a chemically modified Progenipoietins (ProGPs) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting neutrophil-increasing activity than that of the un-modified ProGP, enabling reduced dose and scheduling opportunities.
(FR)L'invention concerne des protéines « progenipoietin » (ProGP) chimiquement modifiées, préparées par la liaison d'un polymère soluble dans l'eau à ladite protéine. La protéine chimiquement modifiée selon l'invention peut présenter une activité d'augmentation des neutrophiles dont la durée est beaucoup plus importante que celle du ProGP non modifié, ce qui permet d'obtenir des doses réduites et des possibilités de programmation accrues.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)