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1. (WO2003000021) PANCAM NUCLEIC ACIDS AND POLYPEPTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2003/000021 International Application No.: PCT/US2002/020275
Publication Date: 03.01.2003 International Filing Date: 24.06.2002
Chapter 2 Demand Filed: 17.01.2003
IPC:
A61K 38/00 (2006.01) ,C07K 14/705 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
Applicants: SUN, Chao[CN/US]; US (UsOnly)
CARULLI, John, P.[US/US]; US (UsOnly)
LUKASHIN, Alexander, V.[US/US]; US (UsOnly)
KILBURN, Daniel, R.[US/US]; US (UsOnly)
GARDNER, Humphrey, Athelstan, Roy[CA/US]; US (UsOnly)
BIOGEN, INC.[US/US]; 14 Cambridge Center Cambridge, MA 02142, US (AllExceptUS)
Inventors: SUN, Chao; US
CARULLI, John, P.; US
LUKASHIN, Alexander, V.; US
KILBURN, Daniel, R.; US
GARDNER, Humphrey, Athelstan, Roy; US
Agent: HALEY, James, F. ; Fish & Neave 1251 Avenue of the Americas New York, NY 10020, US
Priority Data:
PCT/US01/1990422.06.2001US
Title (EN) PANCAM NUCLEIC ACIDS AND POLYPEPTIDES
(FR) ACIDES NUCLEIQUES ET POLYPEPTIDES PANCAM
Abstract:
(EN) An isolated polynucleotide encoding a novel immunoglobulin superfamily member named PanCAM (also named GP354) is provided. PanCAM has a predicted single membrane spanning domain and five immunoglobulin (Ig) domains in the extracellular portion of the protein. The protein structure and tissue distribution of PanCAM indicate that it plays a role in cell-cell recognition, binding, signaling and adhesion events in the pancreas (especially the beta islets), the pituitary gland, and the central nervous system (CNS). Provided by the invention are isolated PanCAM related polynucleotides and polypeptides, vectors, and host cells comprising any of the above, antibodies directed to PanCAM, cells which produce such antibodies, and related diagnostic and therapeutic methods.
(FR) L'invention concerne un polynucléotide isolé codant pour un nouveau membre de la superfamille des immunoglobulines appelé PanCAM (également appelé GP354). PanCAM comprend un domaine transmembranaire unique prédit et cinq domaines de type immunoglobuline (Ig) dans la partie extracellulaire de la protéine. La structure protéique et la répartition tissulaire de PanCAM indiquent que cette dernière joue un rôle dans les événements de reconnaissance, de liaison, de signalisation et d'adhérence entre cellules, dans le pancréas (en particulier dans les îlots bêta), l'hypophyse, et le système nerveux central (SNC). L'invention concerne également des polynucléotides et des polypeptides isolés apparentés à PanCAM, des vecteurs et des cellules hôtes comprenant l'un de ceux-ci, des anticorps dirigés contre PanCAM, des cellules produisant de tels anticorps, et des méthodes diagnostiques et thérapeutiques connexes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)