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1. WO2002103024 - STABILIZED PROTEINS WITH ENGINEERED DISULFIDE BONDS

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Publication Number WO/2002/103024
Publication Date 27.12.2002
International Application No. PCT/US2002/019017
International Filing Date 14.06.2002
Chapter 2 Demand Filed 24.12.2002
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 1/107 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
107by chemical modification of precursor peptides
C07K 14/745 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
745Blood coagulation or fibrinolysis factors
C07K 14/755 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
745Blood coagulation or fibrinolysis factors
755Factors VIII
C12N 9/64 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
C12N 9/74 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
74Thrombin
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61P 7/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
C07K 1/107
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
107by chemical modification of precursor peptides
C07K 1/1075
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
107by chemical modification of precursor peptides
1072by covalent attachment of residues or functional groups
1075by covalent attachment of amino acids or peptide residues
C07K 14/745
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
745Blood coagulation or fibrinolysis factors
Applicants
  • THE SCRIPPS RESEARCH INSTITUTE [US]/[US] (AllExceptUS)
  • GRIFFIN, John, H. [US]/[US] (UsOnly)
  • GALE, Andrew, J. [US]/[US] (UsOnly)
  • GETZOFF, Elizabeth, D. [US]/[US] (UsOnly)
  • PELLEQUER, Jean-Luc [FR]/[FR] (UsOnly)
Inventors
  • GRIFFIN, John, H.
  • GALE, Andrew, J.
  • GETZOFF, Elizabeth, D.
  • PELLEQUER, Jean-Luc
Agents
  • MORRY, Mary, J.
Priority Data
60/298,57814.06.2001US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) STABILIZED PROTEINS WITH ENGINEERED DISULFIDE BONDS
(FR) PROTEINES STABILISEES AVEC DES LIAISONS DISULFURE GENETIQUEMENT MODIFIEES
front page image
Abstract
(EN) The present invention relates to methods of introducing one or more cysteine residues into a polypeptide which permit the stabilization of the polypeptide by formation of at least one bond, preferably a disulfide bond, between different domains of the polypeptide (Figure 1).
(FR) La présente invention concerne des procédés d'insertion d'un ou des résidus de cystéine dans un polypeptide permettant la stabilisation du polypeptide par la formation d'au moins une liaison, de préférence une liaison disulfure, entre les domaines du polypeptide. L'invention concerne également des polypeptides contenant un/de tel(s) résidu(s) de cystéine, de acides nucléiques codant pour de tels polypeptides et des compositions pharmaceutiques comprenant de tels polypeptides ou acides nucléiques. L'invention concerne en outre des vecteurs, des particules virales et des cellules hôtes contenant de tels acides nucléiques, et des procédés pour leur mise en oeuvre en vue de produire des polypeptides de l'invention. Des exemples de tels polypeptides comprennent les protéines plasmatiques, y compris la protéine d'activation de croissance des hépatocytes et la protéine de liaison à l'hyaluronine plasmatique, ainsi que les facteurs de coagulation sanguine, tels que le Facteur VIII, le Facteur V, le Facteur XII et la prothrombine.
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