WO2002102414 MEDICINAL COMPOSITIONS

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Publication Number WO/2002/102414

Publication Date 27.12.2002

International Application No. PCT/JP2002/005954

International Filing Date 14.06.2002

Chapter 2 Demand Filed 08.11.2002

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Applicants

OTSUKA PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
KIMURA, Toshikiro [JP]/[JP] (UsOnly)
HIGAKI, Kazutaka [JP]/[JP] (UsOnly)
MIYAKE, Masateru [JP]/[JP] (UsOnly)
MINAMI, Takanori [JP]/[JP] (UsOnly)

Inventors

KIMURA, Toshikiro
HIGAKI, Kazutaka
MIYAKE, Masateru
MINAMI, Takanori

Agents

SAEGUSA, Eiji

Priority Data

2001-180373		14.06.2001		JP
2001-298839		28.09.2001		JP

Publication Language Japanese (ja)

Filing Language Japanese (JA)

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Title

(EN) MEDICINAL COMPOSITIONS

(FR) COMPOSITIONS MEDICINALES

Abstract

(EN) Medicinal compositions containing: (1) a pharmacologically active substance; (2) a drug sorbefacient; and (3) a taurine compound or a polyamine. A taurine compound has an effect of lessening or preventing injuries on the intestinal mucosa. By adding the taurine compound to medicinal compositions containing a pharmacologically active substance and a drug sorbefacient, therefore, injuries on the intestinal mucosa due to the drug sorbefacient can be lessened or prevented. A polyamine has an effect of improving the absorbability of a pharmacologically active substance. By adding the polyamine to medicinal compositions containing a pharmacologically active substance and a drug sorbefacient, therefore, the dose of the drug sorbefacient can be decreased and thus injuries on intestinal mucosa can be lessened or prevented.

(FR) L'invention concerne des compositions médicinales contenant(1) une substance active au niveau pharmacologique, (2) une substance absorbefaciente et (3) un composé de taurine ou une polyamine. Le composé de taurine permet de diminuer ou d'empêcher les blessures de la muqueuse intestinale. Grâce à l'ajout du composé de taurine à des compositions médicinales contenant une substance active au niveau pharmacologique et une substance absorbefaciente, les blessures de la muqueuse intestinale dues à la substance absorbefaciente peuvent être diminuées ou empêchées. La polyamine améliore la capacité d'absorption d'une substance active au niveau pharmacologique. Grâce à l'ajout de polyamine à des compositions médicinales contenant une substance active au niveau pharmacologique et une substance absorbefaciente, la dose de substance absorbefaciente peut être diminuée et par conséquent les blessures de la muqueuse intestinale peuvent être diminuées ou empêchées.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
38	having sulfur as a ring hetero atom

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
47	Quinolines; Isoquinolines
4704	2-Quinolinones, e.g. carbostyril

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
47	Quinolines; Isoquinolines
4709	Non-condensed quinolines containing further heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08	containing oxygen
12	Carboxylic acids; Salts or anhydrides thereof

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1. WO2002102414 - MEDICINAL COMPOSITIONS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system
04	for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
141	Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
145	with organic compounds

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16	Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605	Excipients; Inactive ingredients
1617	Organic compounds, e.g. phospholipids, fats

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16	Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605	Excipients; Inactive ingredients
1629	Organic macromolecular compounds
1641	obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
20	Pills, tablets, ; discs, rods
2004	Excipients; Inactive ingredients
2022	Organic macromolecular compounds
2031	obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers