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1. WO2002102414 - MEDICINAL COMPOSITIONS

Publication Number WO/2002/102414
Publication Date 27.12.2002
International Application No. PCT/JP2002/005954
International Filing Date 14.06.2002
Chapter 2 Demand Filed 08.11.2002
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 31/38 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
A61K 31/4704 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
47042-Quinolinones, e.g. carbostyril
A61K 31/4709 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines containing further heterocyclic rings
A61K 47/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
CPC
A61K 31/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
A61K 31/4704
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
47042-Quinolinones, e.g. carbostyril
A61K 31/4709
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines and containing further heterocyclic rings
A61K 47/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
A61K 47/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
20containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Applicants
  • OTSUKA PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • KIMURA, Toshikiro [JP]/[JP] (UsOnly)
  • HIGAKI, Kazutaka [JP]/[JP] (UsOnly)
  • MIYAKE, Masateru [JP]/[JP] (UsOnly)
  • MINAMI, Takanori [JP]/[JP] (UsOnly)
Inventors
  • KIMURA, Toshikiro
  • HIGAKI, Kazutaka
  • MIYAKE, Masateru
  • MINAMI, Takanori
Agents
  • SAEGUSA, Eiji
Priority Data
2001-18037314.06.2001JP
2001-29883928.09.2001JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) MEDICINAL COMPOSITIONS
(FR) COMPOSITIONS MEDICINALES
Abstract
(EN) Medicinal compositions containing: (1) a pharmacologically active substance; (2) a drug sorbefacient; and (3) a taurine compound or a polyamine. A taurine compound has an effect of lessening or preventing injuries on the intestinal mucosa. By adding the taurine compound to medicinal compositions containing a pharmacologically active substance and a drug sorbefacient, therefore, injuries on the intestinal mucosa due to the drug sorbefacient can be lessened or prevented. A polyamine has an effect of improving the absorbability of a pharmacologically active substance. By adding the polyamine to medicinal compositions containing a pharmacologically active substance and a drug sorbefacient, therefore, the dose of the drug sorbefacient can be decreased and thus injuries on intestinal mucosa can be lessened or prevented.
(FR) L'invention concerne des compositions médicinales contenant (1) une substance active au niveau pharmacologique, (2) une substance absorbefaciente et (3) un composé de taurine ou une polyamine. Le composé de taurine permet de diminuer ou d'empêcher les blessures de la muqueuse intestinale. Grâce à l'ajout du composé de taurine à des compositions médicinales contenant une substance active au niveau pharmacologique et une substance absorbefaciente, les blessures de la muqueuse intestinale dues à la substance absorbefaciente peuvent être diminuées ou empêchées. La polyamine améliore la capacité d'absorption d'une substance active au niveau pharmacologique. Grâce à l'ajout de polyamine à des compositions médicinales contenant une substance active au niveau pharmacologique et une substance absorbefaciente, la dose de substance absorbefaciente peut être diminuée et par conséquent les blessures de la muqueuse intestinale peuvent être diminuées ou empêchées.
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