WO2002096866 THIOLALKYL BENZOIC ACID DERIVATIVES

Settings

Stemming

Single Family Member

Include NPL

Feedback

Goto Application

Publication Number WO/2002/096866

Publication Date 05.12.2002

International Application No. PCT/US2002/016971

International Filing Date 30.05.2002

IPC

CPC

View more classifications

View less classifications

Applicants

GUILFORD PHARMACEUTICALS INC. [US]/[US]

Inventors

TSUKAMOTO, Takashi
STOERMER, Doris
VITHARANA, Dilrukshi

Agents

ROUGET, F., HENSCHEL

Priority Data

60/294,036		30.05.2001		US
60/342,746		28.12.2001		US

Publication Language English (en)

Filing Language English (EN)

Designated States

View all

Title

(EN) THIOLALKYL BENZOIC ACID DERIVATIVES

(FR) DERIVES D'ACIDE THIOLALKYLBENZOIQUE

Abstract

(EN) The present invention relates to thiolalkyl benzoic acids of the Formulae (Ia), (Ib) and (I) (in which the variables are as defined in the claims), pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, glaucoma and retinal disorders.

(FR) L'invention concerne des acides thiolalkylbenzoïques, des compositions pharmaceutiques et des kits de diagnostic contenant de tels composés, ainsi que des procédés d'utilisation de ces composés permettant d'inhiber l'activité d'enzyme NAALADase, de détecter des maladies dans lesquelles des niveaux de NAALADase sont altérés, d'apporter une activité neuronale, d'apporter une activité de TGF-&bgr;, d'inhiber l'angiogénèse, et de traiter les anomalies du glutamate, la neuropathie, la douleur, les troubles compulsifs, les maladies de la prostate, les troubles rétiniens et le cancer.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
323	Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50	containing thio groups and carboxyl groups bound to the same carbon skeleton
51	having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
56	the carbon skeleton containing six-membered aromatic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
323	Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50	containing thio groups and carboxyl groups bound to the same carbon skeleton
51	having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
57	the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
58	with amino groups bound to the carbon skeleton

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
323	Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50	containing thio groups and carboxyl groups bound to the same carbon skeleton
62	having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
323	Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50	containing thio groups and carboxyl groups bound to the same carbon skeleton
51	having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
56	the carbon skeleton containing six-membered aromatic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
323	Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50	containing thio groups and carboxyl groups bound to the same carbon skeleton
51	having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
57	the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
58	with amino groups bound to the carbon skeleton

Processing

National Phase Entries

Authority File

Settings

Feedback

Goto Application

1. WO2002096866 - THIOLALKYL BENZOIC ACID DERIVATIVES

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13	Drugs for disorders of the urinary system