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1. WO2002096866 - THIOLALKYL BENZOIC ACID DERIVATIVES

Publication Number WO/2002/096866
Publication Date 05.12.2002
International Application No. PCT/US2002/016971
International Filing Date 30.05.2002
IPC
C07C 323/56 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
56the carbon skeleton containing six-membered aromatic rings
C07C 323/58 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
57the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
58with amino groups bound to the carbon skeleton
C07C 323/62 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
62having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
CPC
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 19/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
04for non-specific disorders of the connective tissue
Applicants
  • GUILFORD PHARMACEUTICALS INC. [US]/[US]
Inventors
  • TSUKAMOTO, Takashi
  • STOERMER, Doris
  • VITHARANA, Dilrukshi
Agents
  • ROUGET, F., HENSCHEL
Priority Data
60/294,03630.05.2001US
60/342,74628.12.2001US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) THIOLALKYL BENZOIC ACID DERIVATIVES
(FR) DERIVES D'ACIDE THIOLALKYLBENZOIQUE
Abstract
(EN) The present invention relates to thiolalkyl benzoic acids of the Formulae (Ia), (Ib) and (I) (in which the variables are as defined in the claims), pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, glaucoma and retinal disorders.
(FR) L'invention concerne des acides thiolalkylbenzoïques, des compositions pharmaceutiques et des kits de diagnostic contenant de tels composés, ainsi que des procédés d'utilisation de ces composés permettant d'inhiber l'activité d'enzyme NAALADase, de détecter des maladies dans lesquelles des niveaux de NAALADase sont altérés, d'apporter une activité neuronale, d'apporter une activité de TGF-&bgr;, d'inhiber l'angiogénèse, et de traiter les anomalies du glutamate, la neuropathie, la douleur, les troubles compulsifs, les maladies de la prostate, les troubles rétiniens et le cancer.
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