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1. (WO2002092795) INTRACELLULAR BONDING OF COSTIMULATORY MOLECULES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2002/092795 International Application No.: PCT/EP2002/005403
Publication Date: 21.11.2002 International Filing Date: 16.05.2002
Chapter 2 Demand Filed: 14.11.2002
IPC:
A61P 37/00 (2006.01) ,C12N 5/0784 (2010.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0784
Dendritic cells; Progenitors thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
GENETHOR GMBH [DE/DE]; Robert-Rössle-Str. 10 13125 Berlin, DE (AllExceptUS)
SHERIFF, Ahmed [DE/DE]; DE (UsOnly)
VOGT, Birgit [DE/DE]; DE (UsOnly)
Inventors:
SHERIFF, Ahmed; DE
VOGT, Birgit; DE
Agent:
MEYERS, Hans-Wilhelm ; Postfach 10 22 41 50462 Köln, DE
Priority Data:
101 23 765.016.05.2001DE
Title (DE) INTRAZELLULÄRE BINDUNG COSTIMULATORISCHER MOLEKÜLE
(EN) INTRACELLULAR BONDING OF COSTIMULATORY MOLECULES
(FR) LIAISON INTRACELLULAIRE DE MOLECULES COSTIMULANTES
Abstract:
(DE) Antigen-präsentierende Zelle oder deren Vorläuferzellen einschließlich Stammzellen, dadurch gekennzeichnet, dass in der antigen-präsentierenden Zelle B7-Rezeptor bindende Moleküle produziert werden, welche Rezeptoren der B7-Familie intrazellulär binden.Die Erfindung beruht auf einer Reduktion von spezifischen Immunreaktionen. Bei dem Verfahren werden Antigen-produzierende Zellen zur Unterdrückung von Abstoßungsreaktionen gegen Transplantate veranlasst.
(EN) The invention relates to antigen-presenting cells or the precursory cells thereof including stem cells. The invention is characterised in that in the antigen-presenting cells produce B7-receptor bonding molecules, which bind receptors of the B7-family in an intercellular manner. The invention is based on a reduction of specific immune reactions. According to said method, antigen-presenting cells lead to the suppression of rejection reactions to transplants.
(FR) L'invention concerne une cellule présentatrice d'antigène ou des cellules précurseurs de celle-ci, notamment des cellules souches. L'invention se caractérise en ce que des molécules se liant à des récepteurs B7 sont produites dans ladite cellule présentatrice d'antigène, ces molécules se liant à des récepteurs de la famille B7 de façon intracellulaire. L'invention repose sur une réduction de réactions immunitaires spécifiques. Selon le procédé, des cellules présentatrices d'antigène sont amenées à éliminer les réactions de rejet de greffes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)