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1. (WO2002088110) QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE
Latest bibliographic data on file with the International Bureau
Pub. No.: WO/2002/088110 International Application No.: PCT/JP2002/004279
Publication Date: 07.11.2002 International Filing Date: 26.04.2002
Chapter 2 Demand Filed: 26.04.2002
IPC:
C07D 413/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
KIRIN BEER KABUSHIKI KAISHA [JP/JP]; 10-1, Shinkawa 2-chome Chuo-ku, Tokyo 104-8288, JP (AllExceptUS)
KUBO, Kazuo [JP/JP]; JP (UsOnly)
SAKAI, Teruyuki [JP/JP]; JP (UsOnly)
NAGAO, Rika [JP/JP]; JP (UsOnly)
FUJIWARA, Yasunari [JP/JP]; JP (UsOnly)
ISOE, Toshiyuki [JP/JP]; JP (UsOnly)
HASEGAWA, Kazumasa [JP/JP]; JP (UsOnly)
Inventors:
KUBO, Kazuo; JP
SAKAI, Teruyuki; JP
NAGAO, Rika; JP
FUJIWARA, Yasunari; JP
ISOE, Toshiyuki; JP
HASEGAWA, Kazumasa; JP
Agent:
YOSHITAKE, Kenji ; Kyowa Patent & Law Office Room 323, Fuji Bldg. 2-3, Marunouchi 3-chome Chiyoda-ku, Tokyo 100-0005, JP
Priority Data:
2001-13277527.04.2001JP
Title (EN) QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE
(FR) DERIVES DE QUINOLINE AYANT UN GROUPE AZOLYLE ET DERIVES DE QUINAZOLINE
Abstract:
(EN) A compound having strong antitumor activity. It is a compound represented by the formula (I) or a pharmaceutically acceptable salt or solvate thereof: (I) wherein X and Z each represents CH or nitrogen; Y represents oxygen or sulfur; R1, R2, and R3 each represents hydrogen, alkoxy, etc.; R4 represents hydrogen; R5, R6, R7, and R8 each represents hydrogen, halogeno, alkoxy, etc.; R9 and R10 each represents hydrogen, alkyl, etc.; and R11 represents optionally substituted azolyl.
(FR) L'invention concerne un composé ayant une forte activité antitumorale. C'est un composé représenté par la formule (I) ou un sel ou solvate pharmaceutiquement acceptable de ce dernier. Dans la formule (I), X et Z représentent respectivement CH ou azote ; Y représente oxygène ou soufre ; R1, R2 et R3 représentent respectivement hydrogène, alcoxy etc. ; R4 représente hydrogène ; R5, R6, R7 et R8 représentent respectivement hydrogène, halogène, alcoxy etc. ; R9 et R10 représentent respectivement hydrogène, alkyle etc. ; et R11 représentent un azolyle éventuellement substitué.
 front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
NO20034595PLP.367105MXPA/a/2003/009662KR1020040015143ZA2003/07861IL158459
ES2256466BRPI0209216EP1382604EP1652847JP2004224800JP2010077131
RU02283841US20030087907US20040229876JP2003012668 CN1543459CA2445333
DE000060208364NZ529046AU2002255284DK1382604BRPI0209216ID038.662
IN1649/DELNP/2003PT1382604