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1. WO2002087481 - PREVENTION OF MYOCARDIAL INFARCTION INDUCED VENTRICULAR EXPANSION AND REMODELING

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

WHAT IS CLAIMED IS:
1. A method for direct localized therapeutic treatment of myocardial tissue in heart having a pathological condition comprising the steps of:
a. identifying a target region of the myocardium;
b. applying material directly and substantially only to at least a
portion of the myocardial tissue of the target region substantially identified in step (a) to physically modify the mechanical
properties of said tissue.
2. The method of claim 1 wherein the modified mechanical properties
include an increase in systolic performance.
3. The method of claim 2 wherein the modified mechanical properties
include substantially no decrease in global diastolic performance.
4. The method of claim 1 , wherein the material applied is passive.
5. The method of claim 1 , wherein said target region includes a
myocardial infarct.
6. The method of claim 1, wherein said target region at least in part
underlies the papillary muscles associated with a cardiac valve.
7. The method of claim 6, wherein said cardiac valve is the mitral valve.

8. The method of claim 1 , wherein said material applied to the myocardial tissue is a device.
9. The method of claim 1 , wherein said material applied to the myocardial tissue comprises a polymer.
10. The method of claim 1 , wherein said material applied to the myocardial tissue comprises microspheres.
11. The method of claim 1 , wherein said material applied to the myocardial tissue comprises a bioactive agent.
12. The method of claim 1, wherein said applying step includes employing a catheter.

13. The method of claim 12 wherein said catheter is employed percutaneously.
14. The method of claim 1 , wherein said applying step is preceded by performing a mini-thoracotomy.
15. The method of claim 1 , wherein said applying step includes applying material intramyocardially.