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1. (WO2002081628) MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATION PROLIFERATION AND NEURITE OUTGROWTH, USING NUCLEIC ACID BASED TECHNOLOGIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2002/081628 International Application No.: PCT/US2002/010512
Publication Date: 17.10.2002 International Filing Date: 03.04.2002
Chapter 2 Demand Filed: 08.10.2002
IPC:
A61K 38/00 (2006.01) ,C12N 15/11 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
BLATT, Lawrence [US/US]; US (UsOnly)
CHOWRIRA, Bharat [US/US]; US (UsOnly)
HAEBERLI, Peter [US/US]; US (UsOnly)
MCSWIGGEN, James [US/US]; US (UsOnly)
FOSNAUGH, Kathy [US/US]; US (UsOnly)
RIBOZYME PHARMACEUTICALS, INCORPORATED [US/US]; 2950 Wilderness Place Boulder, CO 80301, US (AllExceptUS)
Inventors:
BLATT, Lawrence; US
CHOWRIRA, Bharat; US
HAEBERLI, Peter; US
MCSWIGGEN, James; US
FOSNAUGH, Kathy; US
Agent:
HILLMAN, Lisa, M., W.; McDonnell Boehnen Hulbert & Berghoff Suite 3200 300 South Wacker Drive Chicago, IL 60606, US
Priority Data:
09/827,39505.04.2001US
60/294,41229.05.2001US
60/315,31528.08.2001US
Title (EN) MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATION PROLIFERATION AND NEURITE OUTGROWTH, USING NUCLEIC ACID BASED TECHNOLOGIES
(FR) MODULATION DE L'EXPRESSION GENIQUE ASSOCIEE A LA PROLIFERATION INFLAMMATOIRE ET A LA CROISSANCE DE NEURITES, PAR DES PROCEDES FAISANT INTERVENIR L'ACIDE NUCLEIQUE
Abstract:
(EN) The present invention relates to nucleic acid molecules, including antisense, enzymatic nucleic acid molecules, and RNA interference molecules, such as hammerhead ribozymes, DNAzymes, allozymes, siRNA, decoys and antisense, which modulate the expression of prostaglandin D2 (PTGDS), prostaglandin D2 receptor (PTGDR), adenosine receptor, NOGO and NOGO receptor, and IKK genes, such as IKK-gamma, IKK-alpha, or IKK-beta, and PKR genes.
(FR) L'invention concerne des molécules d'acide nucléique comprenant des molécules d'acide nucléique enzymatique antisens et des molécules d'interférence de l'ARN telles que ribozymes en tête de marteau, ADN-zymes, allozymes, ARNsi, leurres et antisens qui modulent l'expression du récepteur de la prostaglandine D2 (PTGDR), du récepteur de l'adénosine, de NOGO et du récepteur de NOGO et des gènes IKK tels que IKK-gamma, IKK-alpha, ou IKK-beta, et des gènes PKR.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)