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1. (WO2002068438) 9A-N-[N'-(PHENYLSULFONYL)CARBAMOYL] DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHROMYCIN A AND OF 5-0-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHRONOLIDE A
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2002/068438 International Application No.: PCT/HR2002/000010
Publication Date: 06.09.2002 International Filing Date: 27.02.2002
Chapter 2 Demand Filed: 24.09.2002
IPC:
C07H 17/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Applicants:
KUJUNDZIC, Nedjeljko [HR/HR]; HR (UsOnly)
BUKVIC KRAJACIC, Mirjana [HR/HR]; HR (UsOnly)
DUMIC, Miljenko [HR/HR]; HR (UsOnly)
HASENOHRL, Andrea [HR/HR]; HR (UsOnly)
PLIVA D.D. [HR/HR]; Ulica Grada Vikovara 49 HR-10000 Zagreb, HR (AllExceptUS)
Inventors:
KUJUNDZIC, Nedjeljko; HR
BUKVIC KRAJACIC, Mirjana; HR
DUMIC, Miljenko; HR
HASENOHRL, Andrea; HR
Agent:
PLIVA D.D.; Ulica Grada Vikovara 49 HR-10000 Zagreb, HR
Priority Data:
P20010146A28.02.2001HR
Title (EN) 9A-N-[N'-(PHENYLSULFONYL)CARBAMOYL] DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHROMYCIN A AND OF 5-0-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHRONOLIDE A
(FR) DERIVES 9A-N-[N'-(PHENYLSULFONYL)CARBAMOYL] DE 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHROMYCIN A ET DE 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHRONOLIDE A
Abstract:
(EN) The invention relates to 9a-N[N'-(phenylsulfonyl)carbamoyl] derivatives of 9-deoxo-9-dihydro-9a-aza-homoerythromycin A and 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolide A, novel semisynthetic macrolide antibiotics from the class of azalides, of the general formula (I) wherein R1 denotes H, C1-C4alkyl or halogen and R denotes H or cladinosyl radical, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to intermediates and methods for their preparation, to a process for the preparation of pharmaceutical compositions as well as to the use of pharmaceutical compositions in the treatment of bacterial infections.
(FR) L'invention concerne des dérivés 9a-N-[N'-(phénylsulfonyl)carbomoyl] de 9-déoxo-9-dihydro-9a-aza-9a-homoérythromycine A et de 5-O-désosaminyl-9-déoxo-9-dihydro-9a-aza-9a-homoérythronolide A, de nouveaux antibiotiques macrolide semi-synthétiques de la classe des azalides, de formule générale I dans laquelle R1 représente H, alkyl C1-C4 ou halogène et R représente H ou un radical cladinosyl, leurs sels d'addition pharmaceutiquement acceptables avec des acides inorganiques ou organiques, des intermédiaires et des procédés de préparation, ainsi qu'un procédé de préparation de compositions pharmaceutiques et l'utilisation de ces dernières dans le traitement d'infections bactériennes.
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Designated States: AU, BA, CN, CZ, EE, HU, ID, IL, IN, JP, KR, LT, LV, MK, MX, PL, RO, SI, SK, TR, UA, US, YU, ZA
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
Publication Language: English (EN)
Filing Language: English (EN)