Search International and National Patent Collections

1. (WO2002068438) 9A-N-[N'-(PHENYLSULFONYL)CARBAMOYL] DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHROMYCIN A AND OF 5-0-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHRONOLIDE A

Pub. No.:    WO/2002/068438    International Application No.:    PCT/HR2002/000010
Publication Date: Sat Sep 07 01:59:59 CEST 2002 International Filing Date: Thu Feb 28 00:59:59 CET 2002
IPC: C07H 17/00
Applicants: PLIVA D.D.
KUJUNDZIC, Nedjeljko
BUKVIC KRAJACIC, Mirjana
DUMIC, Miljenko
HASENOHRL, Andrea
Inventors: KUJUNDZIC, Nedjeljko
BUKVIC KRAJACIC, Mirjana
DUMIC, Miljenko
HASENOHRL, Andrea
Title: 9A-N-[N'-(PHENYLSULFONYL)CARBAMOYL] DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHROMYCIN A AND OF 5-0-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHRONOLIDE A
Abstract:
The invention relates to 9a-N[N'-(phenylsulfonyl)carbamoyl] derivatives of 9-deoxo-9-dihydro-9a-aza-homoerythromycin A and 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolide A, novel semisynthetic macrolide antibiotics from the class of azalides, of the general formula (I) wherein R1 denotes H, C1-C4alkyl or halogen and R denotes H or cladinosyl radical, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to intermediates and methods for their preparation, to a process for the preparation of pharmaceutical compositions as well as to the use of pharmaceutical compositions in the treatment of bacterial infections.