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1. WO2002068438 - 9A-N-[N'-(PHENYLSULFONYL)CARBAMOYL] DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHROMYCIN A AND OF 5-0-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHRONOLIDE A

Publication Number WO/2002/068438
Publication Date 06.09.2002
International Application No. PCT/HR2002/000010
International Filing Date 27.02.2002
Chapter 2 Demand Filed 24.09.2002
IPC
C07H 17/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
CPC
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07H 17/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Applicants
  • PLIVA D.D. [HR]/[HR] (AllExceptUS)
  • KUJUNDZIC, Nedjeljko [HR]/[HR] (UsOnly)
  • BUKVIC KRAJACIC, Mirjana [HR]/[HR] (UsOnly)
  • DUMIC, Miljenko [HR]/[HR] (UsOnly)
  • HASENOHRL, Andrea [HR]/[HR] (UsOnly)
Inventors
  • KUJUNDZIC, Nedjeljko
  • BUKVIC KRAJACIC, Mirjana
  • DUMIC, Miljenko
  • HASENOHRL, Andrea
Agents
  • PLIVA D.D.
Priority Data
P20010146A28.02.2001HR
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 9A-N-[N'-(PHENYLSULFONYL)CARBAMOYL] DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHROMYCIN A AND OF 5-0-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHRONOLIDE A
(FR) DERIVES 9A-N-[N'-(PHENYLSULFONYL)CARBAMOYL] DE 9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHROMYCIN A ET DE 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9A-AZA-9A-HOMOERYTHRONOLIDE A
Abstract
(EN) The invention relates to 9a-N[N'-(phenylsulfonyl)carbamoyl] derivatives of 9-deoxo-9-dihydro-9a-aza-homoerythromycin A and 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolide A, novel semisynthetic macrolide antibiotics from the class of azalides, of the general formula (I) wherein R1 denotes H, C1-C4alkyl or halogen and R denotes H or cladinosyl radical, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to intermediates and methods for their preparation, to a process for the preparation of pharmaceutical compositions as well as to the use of pharmaceutical compositions in the treatment of bacterial infections.
(FR) L'invention concerne des dérivés 9a-N-[N'-(phénylsulfonyl)carbomoyl] de 9-déoxo-9-dihydro-9a-aza-9a-homoérythromycine A et de 5-O-désosaminyl-9-déoxo-9-dihydro-9a-aza-9a-homoérythronolide A, de nouveaux antibiotiques macrolide semi-synthétiques de la classe des azalides, de formule générale I dans laquelle R1 représente H, alkyl C1-C4 ou halogène et R représente H ou un radical cladinosyl, leurs sels d'addition pharmaceutiquement acceptables avec des acides inorganiques ou organiques, des intermédiaires et des procédés de préparation, ainsi qu'un procédé de préparation de compositions pharmaceutiques et l'utilisation de ces dernières dans le traitement d'infections bactériennes.
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