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1. WO2002057741 - MONOCLONAL ANTIBODIES AND CELL SURFACE ANTIGENS FOR THE DETECTION AND TREATMENT OF SMALL CELL LUNG CANCER (SCLC)

Publication Number WO/2002/057741
Publication Date 25.07.2002
International Application No. PCT/US2001/048403
International Filing Date 01.11.2001
Chapter 2 Demand Filed 31.05.2002
IPC
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
G01N 33/574 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 16/3023
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
3023Lung
C07K 2317/77
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
77Internalization into the cell
Applicants
  • MOLECULAR DISCOVERIES, L.L.C. [US]/[US]
Inventors
  • GELBER, Cohava
Agents
  • SERUNIAN, Leslie, A.
Priority Data
60/245,34002.11.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MONOCLONAL ANTIBODIES AND CELL SURFACE ANTIGENS FOR THE DETECTION AND TREATMENT OF SMALL CELL LUNG CANCER (SCLC)
(FR) ANTICORPS MONOCLONAUX ET ANTIGENES DE SURFACE POUR LA DETECTION ET LE TRAITEMENT DU CANCER A PETITES CELLULES (SCLC)
Abstract
(EN) The invention provides new monoclonal antibodies and binding fragments thereof which recognize and immunoreact with cell surface antigens found on small cell lung cancer (SCLC) cells. The antibodies have tumor specificity and are useful for therapy, diagnosis, monitoring, detecting and imaging of SCLC disease and of patients having SCLC disease. The antibody-recognized SCLC-specific surface antigens can serve as targets for detecting, diagnosing, inhibiting or killing SCLC cells.
(FR) L'invention concerne des nouveaux anticorps monoclonaux et des fragments de liaison de ceux-ci, qui reconnaissent les antigènes de surface que l'on trouve dans les cellules du cancer à petites cellules (SCLC), et qui sont immunoréactifs avec ceux-ci. Les anticorps de l'invention sont spécifiques de certaines tumeurs et sont utiles pour la thérapie, le diagnostic, le contrôle, la détection et l'imagerie de maladies du type SCLC et de patients souffrant de SCLC. Les antigènes de surface spécifiques de SCLC reconnus par les anticorps peuvent servir de cibles pour la détection, le diagnostic, l'inhibition ou l'élimination des cellules de SCLC.
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