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1. WO2002056016 - METHOD FOR IDENTIFYING A LIGAND FOR A BIOLOGICAL SUBSTRATE

Publication Number WO/2002/056016
Publication Date 18.07.2002
International Application No. PCT/US2002/000807
International Filing Date 10.01.2002
Chapter 2 Demand Filed 22.07.2002
IPC
C07D 211/58 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56Nitrogen atoms
58attached in position 4
G01N 33/60 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
60involving radioactive labelled substances
CPC
C07D 211/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56Nitrogen atoms
58attached in position 4
G01N 2500/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
G01N 33/60
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
60involving radioactive labelled substances
Y10S 530/807
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
530Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
807Hapten conjugated with peptide or protein
Applicants
  • THERAVANCE, INC. [US]/[US] (AllExceptUS)
  • MAMMEN, Mathai [CA]/[US] (UsOnly)
Inventors
  • MAMMEN, Mathai
Agents
  • BOONE, David
Priority Data
09/758,91611.01.2001US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR IDENTIFYING A LIGAND FOR A BIOLOGICAL SUBSTRATE
(FR) PROCEDE D'APPLICATION D'UN LIGAND POUR UN SUBSTRAT BIOLOGIQUE
Abstract
(EN) A method of identifying a ligand for a second binding site (5) on a biological substrate (1) is disclosed. The method comprises determining the effect of a candidate compound (9) on the binding of a probe compound (2) which binds to a first binding site (3) on the biological substrate in the presence of a first multibinding compound (4) which binds to the first (3) and second (5) binding sites on the biological substrate (1).
(FR) L'invention porte sur un procédé d'identification d'un ligand destiné à un second site de liaison (5) sur un substrat biologique (1). Ce procédé consiste à déterminer l'effet d'un composé candidat (9) lors de la liaison d'un composé sonde (2) qui se lie à un premier site de liaison (3) sur le substrat biologique en présence d'un premier composé multiliaison (4) qui se lie aux premier et second sites de liaison sur le substrat biologique (1).
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