Processing

Please wait...

Settings

Settings

Goto Application

1. WO2002042452 - ADAPTER PROTEIN AND GENE ENCODING IT

Publication Number WO/2002/042452
Publication Date 30.05.2002
International Application No. PCT/CA2001/001662
International Filing Date 26.11.2001
Chapter 2 Demand Filed 24.06.2002
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/4703
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
4703Inhibitors; Suppressors
Applicants
  • THE HOSPITAL FOR SICK CHILDREN [CA]/[CA] (AllExceptUS)
  • MCGLADE, Jane, C. [CA]/[CA] (UsOnly)
  • LORETO, Michael, P. [CA]/[CA] (UsOnly)
Inventors
  • MCGLADE, Jane, C.
  • LORETO, Michael, P.
Agents
  • BARTOSZEWICZ, Lola, A.
Priority Data
2,324,66327.11.2000CA
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ADAPTER PROTEIN AND GENE ENCODING IT
(FR) GENE ADAPTATEUR
Abstract
(EN)
The present invention relates to the identification and cloning of a novel gene, MARS (Modulator of Antigen Receptor Signaling), which is a putative tumor suppressor gene. The present invention also relates to the relation of the MARS gene to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the MARS gene, or lack the MARS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
(FR)
La présente invention concerne l'identification et le clonage d'un nouveau gène appelé MARS (modulateur de la signalisation du récepteur d'antigène) qui est un gène de suppression des tumeurs présumé; ainsi que la relation existant entre le gène MARS et des cancers chez l'homme et l'utilisation de ce gène dans le diagnostic et le pronostic du cancer chez l'homme. Cette invention concerne également la thérapie des cancers chez l'homme pour lesquels il existe une mutation dans le gène MARS ou bien pour lesquels ledit gène MARS est manquant, la thérapie des cancers comprenant la thérapie génique, la thérapie par remplacement de protéines et les mimétiques de protéines; ainsi que le criblage de médicaments pour la thérapie anticancéreuse.
Latest bibliographic data on file with the International Bureau