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1. WO2002041878 - TITRATABLE DOSAGE TRANSDERMAL DELIVERY SYSTEM

Publication Number WO/2002/041878
Publication Date 30.05.2002
International Application No. PCT/US2001/051197
International Filing Date 13.11.2001
Chapter 2 Demand Filed 13.06.2002
IPC
A61K 9/70 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases
CPC
A61F 2013/0296
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
13Bandages or dressings
02Adhesive plasters or dressings
0276Apparatus or processes for manufacturing adhesive dressings or bandages
0296for making transdermal patches (chemical processes excluded)
A61K 31/4468
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4468having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
A61K 31/485
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61K 9/703
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases ; ; Films; Fibres of the matrix type containing drug;
7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
703characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
A61K 9/7038
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases ; ; Films; Fibres of the matrix type containing drug;
7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
703characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
A61K 9/7084
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases ; ; Films; Fibres of the matrix type containing drug;
7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
703characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Applicants
  • EURO-CELTIQUE, S.A. [LU]/[LU] (AllExceptUS)
  • WRIGHT, Curtis [US]/[US] (UsOnly)
Inventors
  • WRIGHT, Curtis
Agents
  • STERN, Gidon, D.
Priority Data
09/714,60416.11.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TITRATABLE DOSAGE TRANSDERMAL DELIVERY SYSTEM
(FR) SYSTEME D'ADMINISTRATION TRANSDERMIQUE DE DOSES TITRABLES
Abstract
(EN)
The present invention relates to a titratable dosage transdermal delivery system for systemic delivery of a therapeutic agent or drug. The system comprises a plurality of patch units that are connected along one or more borders. The plurality of patch units are divisible into units along the one or more borders having one or more lines of separation. Each patch unit is surrounded by a border. The therapeutic patch has at least a backing layer and a therapeutic agent comprising layer. The dosage of therapeutic agent delivered to a patient is proportional to the number of patch unit applied per treatment. The system enables systemic administration of a titratable dosage of therapeutic agent, adjustable by the patient under the direction of a physician, through the skin or mucosa. Moreover, the invention relates to a method of making the titratable dosage transdermal delivery system. Furthermore, the invention relates to a method of providing a titratable amount of therapeutic agent to a patient using the transdermal delivery system of the invention.
(FR)
L'invention concerne un système d'administration transdermique de doses titrables servant à administrer par voie générale un agent thérapeutique, ou un médicament. Ce système contient un groupe de plusieurs unités de timbres assemblées le long d'un ou de plusieurs bords. Ce groupe d'unités de timbres est divisible en unités au le long d'un ou de plusieurs bords comportant une ou plusieurs lignes de séparation. Chaque unité de timbre est entourée d'un bord. Le timbre thérapeutique comporte au moins une couche de base et une couche contenant un agent thérapeutique. La dose de l'agent thérapeutique administré au patient est proportionnelle au nombre d'unités de timbres appliquées par traitement. Ce système permet d'administrer par voie générale une dose titrable d'agent thérapeutique, pouvant être ajustée par le patient sous contrôle médical, via la peau ou une muqueuse. L'invention concerne également un procédé de fabrication de ce système d'administration transdermique de doses titrables. Par ailleurs, l'invention concerne une méthode d'administration d'une quantité titrable d'agent thérapeutique à un patient, faisant intervenir le système d'administration transdermique de l'invention.
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