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1. WO2002036175 - SUSTAINED RELEASE DEVICE FOR TREATING CONDITIONS OF THE JOINT

Publication Number WO/2002/036175
Publication Date 10.05.2002
International Application No. PCT/US2001/042895
International Filing Date 02.11.2001
Chapter 2 Demand Filed 30.05.2002
IPC
A61B 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
A61B 17/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
16Osteoclasts; Drills or chisels for bones; Trepans
A61B 17/88 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
58for osteosynthesis, e.g. bone plates, screws or the like
88Methods or means for implanting or extracting internal fixation devices
A61F 2/30 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
30Joints
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61L 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
14Materials characterised by their function or physical properties
16Biologically active materials, e.g. therapeutic substances
CPC
A61B 17/0642
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
064Surgical staples, ; i.e. penetrating the tissue
0642for bones, e.g. for osteosynthesis or connecting tendon to bone
A61B 17/1615
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
16Bone cutting, breaking or removal means other than saws, e.g.; Osteoclasts; Drills or chisels for bones; Trepans
1613Component parts
1615Drill bits, i.e. rotating tools extending from a handpiece to contact the worked material
A61B 17/80
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
58for osteosynthesis, e.g. bone plates, screws, ; setting implements; or the like
68Internal fixation devices ; , including fasteners and spinal fixators, even if a part thereof projects from the skin
80Cortical plates ; , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
A61B 17/82
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
58for osteosynthesis, e.g. bone plates, screws, ; setting implements; or the like
68Internal fixation devices ; , including fasteners and spinal fixators, even if a part thereof projects from the skin
82for bone cerclage
A61B 17/8615
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
58for osteosynthesis, e.g. bone plates, screws, ; setting implements; or the like
68Internal fixation devices ; , including fasteners and spinal fixators, even if a part thereof projects from the skin
84Fasteners therefor ; or fasteners being internal fixation devices
86Threaded wires; , pins or screws; ; Nuts therefor
8605Heads, i.e. proximal ends projecting from bone
861specially shaped for gripping driver
8615at the central region of the screw head
A61B 17/8877
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
58for osteosynthesis, e.g. bone plates, screws, ; setting implements; or the like
88Osteosynthesis instruments;; Methods or means for implanting or extracting internal ; or external; fixation devices
8875Screwdrivers, spanners or wrenches
8877characterised by the cross-section of the driver bit
Applicants
  • CONTROL DELIVERY SYSTEMS [US]/[US]
Inventors
  • WATSON, David, A.
  • SMITH, Thomas, J.
  • LAPORTE, Richard
  • GUO, Hong
  • CHEN, Jianbing
  • ASHTON, Paul
  • SMITH, James, A.
Agents
  • MAZZARESE, Robert, A.
Priority Data
60/245,18403.11.2000US
60/255,15714.12.2000US
60/291,60618.05.2001US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUSTAINED RELEASE DEVICE FOR TREATING CONDITIONS OF THE JOINT
(FR) DISPOSITIF ET PROCEDE AMELIORES DE TRAITEMENT D'ETATS PATHOLOGIQUES D'UNE ARTICULATION
Abstract
(EN)
An implantable drug delivery system is provided including a mechanical member attachable to a portion of a body, a first chamber having an opening configured to receive a sustained release device, a sustained release device, and a removably attachable retainer for retaining the sustained release device in the first chamber. A method for administering a drug to a joint is provided including the steps of positioning a mechanical member in or adjacent a bone, the mechanical member configured to hold a sustained release drug delivery device at a substantially controlled rate. Also provided is a sustained release device intraarticularly implantable into a joint to deliver a therapeutically effective compound within a synovial capsule of the joint such that, in one aspect, the synovial fluid concentration of the compound is greater than the plasma concentration of the compound during the prolonged lifetime of the device, thereby eliminating unwanted systemic side effects and the need for frequent and repeated administrations.
(FR)
L'invention concerne un système implantable d'administration de médicament, comportant un élément mécanique pouvant être fixé à une partie du corps, une première chambre comportant une ouverture configurée pour recevoir un dispositif de libération prolongée, un dispositif de libération prolongée, ainsi qu'un dispositif de retenue, fixé de manière amovible, destiné à retenir le dispositif de libération prolongée dans la première chambre. L'invention concerne également un procédé d'apport de médicament à une articulation, consistant à disposer un élément mécanique dans un os ou à proximité d'un os, cet élément mécanique étant configuré pour maintenir un dispositif d'apport de médicament à libération prolongée portant au moins un médicament qu'il libère à un débit sensiblement régulé. L'invention concerne encore un dispositif de libération prolongée implantable de manière intra-articulaire dans une articulation afin d'apporter un composé thérapeutiquement efficace à l'intérieur d'une capsule synoviale de l'articulation, de sorte que, selon un aspect, la concentration de synovie du composé soit supérieure à la concentration de plasma du composé pendant la durée de vie prolongée du dispositif, ce qui permet d'éviter ainsi des effets secondaires systémiques indésirables et la nécessité de procéder à des administrations fréquentes et répétées.
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