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1. WO2002035216 - MULTILAYER ANALYTICAL ELEMENT AND METHOD FOR DETERMINATION OF ANALYTES IN FLUIDS CONTAINING INTERFERING SUBSTANCES

Publication Number WO/2002/035216
Publication Date 02.05.2002
International Application No. PCT/US2001/029683
International Filing Date 19.09.2001
IPC
G01N 33/52 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
CPC
G01N 33/525
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper ; and including single- and multilayer analytical elements
525Multi-layer analytical elements
Applicants
  • MILLER, Michael, M. [US]/[US]
Inventors
  • MILLER, Michael, M.
Priority Data
09/695,68825.10.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MULTILAYER ANALYTICAL ELEMENT AND METHOD FOR DETERMINATION OF ANALYTES IN FLUIDS CONTAINING INTERFERING SUBSTANCES
(FR) ELEMENT ANALYTIQUE A COUCHES MULTIPLES ET PROCEDE DE DETERMINATION D'ANALYTES DANS DES FLUIDES RENFERMANT DES SUBSTANCES INTERFERANTES
Abstract
(EN)
A method and device is provided for determination of an analyte in a fluid sample in the presence of substances interfering with an assay for the analyte. The methods and device comprise an absorbent pad between the site of application of the sample fluid and the reagent impregnated test pad(s) or layer(s) to selectively remove interfering substances. A preferred embodiment comprises a support element (11) having affixed thereto several layers including an adhesive tape layer (15), a reagent layer (12) and an interference removing layer (13). An aperture (16) may be incorporated into the multilayered device to allowing viewing. Preferred interference removing absorbent pads include polyamide, carbon-impregnated and ion-exchange resin impregnated membranes.
(FR)
L'invention concerne un procédé et un dispositif permettant de déterminer un analyte dans un échantillon fluidique en présence de substances interférant avec un test destiné à l'analyte. Ces méthodes et dispositif comprennent un coussinet absorbant placé entre le site d'application du fluide de l'échantillon et les coussinet(s) ou couche(s) test imprégnés de réactif, de manière à éliminer, de façon sélective, des substances interférantes. Dans un mode de réalisation préféré, le dispositif comprend un élément support (11) présentant plusieurs couches fixées à celui-ci, notamment une couche de ruban adhésif (15), une couche de réactif (12) et une couche d'élimination d'interférence. Une ouverture (16) peut être incorporée dans le dispositif à couches multiples, de manière à permettre une visualisation. Les coussinets absorbants permettant d'éliminer une interférence préférés comprennent du polyamide, des membranes imprégnées de carbone et de résine échangeuse d'ions.
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