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1. WO2002034919 - VARIANTS OF SOLUBLE PYRROLOQUINOLINE QUINONE-DEPENDENT GLUCOSE DEHYDROGENASE

Publication Number WO/2002/034919
Publication Date 02.05.2002
International Application No. PCT/EP2001/012148
International Filing Date 20.10.2001
Chapter 2 Demand Filed 01.03.2002
IPC
C12N 9/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
04acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
CPC
C12N 9/0006
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
0004Oxidoreductases (1.)
0006acting on CH-OH groups as donors (1.1)
Applicants
  • ROCHE DIAGNOSTICS GMBH [DE]/[DE] (DE)
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW)
Inventors
  • KRATZSCH, Peter
  • SCHMUCK, Rainer
  • BUNK, Daniela
  • SHAO, Zhixin
  • THYM, Detlef
  • KNAPPE, Wolfgang-Reinhold
Priority Data
00123512.627.10.2000EP
00127294.719.12.2000EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VARIANTS OF SOLUBLE PYRROLOQUINOLINE QUINONE-DEPENDENT GLUCOSE DEHYDROGENASE
(FR) VARIANTES DE GLUCOSE DESHYDROGENASE SOLUBLE, DEPENDANTE DE LA PYRROLOQUINOLINE QUINONE
Abstract
(EN)
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.
(FR)
La présente invention concerne des variantes améliorées de glucose déshydrogénases solubles, dépendantes de la pyrroloquinoline quinone (PQQ), ci-après désignées s-GDH, des gènes codant les s-GDH mutées, des protéines mutantes de s-GDH présentant une meilleure spécificité de substrat par rapport au glucose, ainsi que différentes applications de ces variantes de s-GDH, notamment dans la détermination de concentrations en sucre, particulièrement en glucose, dans un échantillon.
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