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1. WO2002034903 - NUCLEIC ACID GENERATING THE ABCA7 GENE, MOLECULES MODULATING ITS ACTIVITY AND THERAPEUTIC APPLICATIONS

Publication Number WO/2002/034903
Publication Date 02.05.2002
International Application No. PCT/FR2001/003219
International Filing Date 17.10.2001
Chapter 2 Demand Filed 13.05.2002
IPC
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 15/85
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
Applicants
  • AVENTIS PHARMA S.A. [FR]/[FR] (AllExceptUS)
  • INSERM [FR]/[FR] (AllExceptUS)
  • DENEFLE, Patrice [FR]/[FR] (UsOnly)
  • ROSIER, Marie-Françoise [FR]/[FR] (UsOnly)
  • PRADES, Catherine [FR]/[FR] (UsOnly)
  • ARNOULD-REGUIGNE, Isabelle [FR]/[FR] (UsOnly)
  • OSORIO Y FORTEA, José [FR]/[FR] (UsOnly)
  • DUVERGER, Nicolas [FR]/[FR] (UsOnly)
  • CHIMINI, Giovanna [FR]/[FR] (UsOnly)
Inventors
  • DENEFLE, Patrice
  • ROSIER, Marie-Françoise
  • PRADES, Catherine
  • ARNOULD-REGUIGNE, Isabelle
  • OSORIO Y FORTEA, José
  • DUVERGER, Nicolas
  • CHIMINI, Giovanna
Agents
  • LECCA, Patricia
Priority Data
00/1364924.10.2000FR
60/253,14128.11.2000US
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) NUCLEIC ACID GENERATING THE ABCA7 GENE, MOLECULES MODULATING ITS ACTIVITY AND THERAPEUTIC APPLICATIONS
(FR) ACIDE NUCLEIQUE REGULATEUR DU GENE ABCA7, MOLECULES MODULANT SON ACTIVITE ET APPLICATIONS THERAPEUTIQUES
Abstract
(EN)
The invention concerns a nucleic acid capable of regulating the ABCA7 gene transcription, which codes for a carrier protein capable of intervening in the metabolism of lipids and/or in the process involving the immune system and inflammation. In addition, owing to the position of the gene on the chromosome 19 in q 13, ABCA7 is potentially involved in other pathologies genetically related to said locus. The invention also concerns nucleotide constructs comprising a polynucleotide coding for a polypeptide or a nucleic acid of interest, placed under the control of a nucleic acid regulating the ABCA7 gene. The invention further concerns recombinant vectors, transformed host cells and non-human transgenic mammals comprising a nucleic acid regulating the ABCA7 gene transcription and or said nucleotide construct, and methods for screening molecules or substances capable of modulating the activity of the nucleic acid regulating the ABCA7 gene.
(FR)
La présente invention concerne un acide nucléique capable de réguler la transcription de gène ABCA7, qui code pour une protéine transporteur susceptible de jouer un rôle dans le métabolisme des lipides et/ou dans les processus impliquant le système immunitaire et l'inflammation. Par ailleurs, de par la position du gène sur le chromosome 19 en q13, ABCA7 est potentiellement impliqué dans d'autres pathologies liées génétiquement à ce locus. La présente invention est également relative à des constructions nucléotidiques comprenant un polynucléotide codant pour un polypeptide ou un acide nucléique d'intérêt, placé sous le contrôle d'un acide nucléique régulateur du gène ABCA7. L'invention a également trait à des vecteurs recombinants, des cellules hôtes transformées et des mammifères transgéniques non humains comprenant un acide nucléique régulateur de la transcription du gène ABCA7 ou une construction nucléotidique précitée, ainsi que des procédés pour le criblage de molécules ou de substances capables de moduler l'activité de l'acide nucléique régulateur de gène ABCA7.
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