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1. WO2002034769 - IMMUNOREACTIVE PEPTIDE CTL EPITOPES OF HUMAN CYTOMEGALOVIRUS PP150

Publication Number WO/2002/034769
Publication Date 02.05.2002
International Application No. PCT/US2001/032589
International Filing Date 22.10.2001
Chapter 2 Demand Filed 15.05.2002
IPC
A61K 39/25 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
25Varicella-zoster virus
C07K 14/045 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
03Herpetoviridae, e.g. pseudorabies virus
045Cytomegalovirus
CPC
A61K 2039/5156
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5156expressing foreign proteins
A61K 2039/525
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/25
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
25Varicella-zoster virus
A61P 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
22for herpes viruses
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Applicants
  • CITY OF HOPE [US]/[US]
Inventors
  • DIAMOND, Don, J.
Agents
  • FIGG, E., Anthony
Priority Data
60/241,94420.10.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNOREACTIVE PEPTIDE CTL EPITOPES OF HUMAN CYTOMEGALOVIRUS PP150
(FR) EPITOPES CTL PEPTIDIQUES IMMUNOREACTIFS DU CYTOMEGALOVIRUS PP150
Abstract
(EN)
The invention provides peptides which are immunogenic epitopes recognized by CD8+ class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent cytomegalovirus (HCMV) infection. The peptides are capable of activating CTL in the absence of active viral replication, and thus are useful for eliciting a cellular immune response against HCMV by normal and immunodeficient subjects. Vaccines against HCMV, with and without adjuvants, and immunological and diagnostic reagents are disclosed.
(FR)
L'invention concerne des peptides qui sont des épitopes immunogéniques reconnus par des lymphocytes T cytotoxiques CD8 + de classe I à restriction au CMH chez les patients couvant une infection latente par le cytomégalovirus (HCMV). Ces peptides, qui sont capables d'activer les CTL en l'absence de réplication virale active, conviennent pour éliciter une réponse immunitaire cellulaire contre le HCMV de la part de sujets normaux et de sujets immunodéficients. L'invention concerne également des vaccins contre le HCMV, avec ou sans adjuvants, ainsi que des réactifs immunologiques et de diagnostic.
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