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1. WO2002034717 - SULPHUR-CONTAINING INDIRUBIN DERIVATIVES, PRODUCTION AND USE THEREOF

Considered void:  21.03.2003
Publication Number WO/2002/034717
Publication Date 02.05.2002
International Application No. PCT/EP2001/012007
International Filing Date 17.10.2001
Chapter 2 Demand Filed 18.04.2002
IPC
C07D 209/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32Oxygen atoms
36in position 3, e.g. adrenochrome
C07D 209/40 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
40Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 209/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32Oxygen atoms
36in position 3, e.g. adrenochrome
C07D 209/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
40Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
Applicants
  • SCHERING AKTIENGESELLSCHAFT [DE]/[DE]
Inventors
  • PRIEN, Olaf
  • STEINMEYER, Andreas
  • SIEMEISTER, Gerhard
  • JAUTELAT, Rolf
  • SCHÄFER, Martina
Priority Data
100 53 474.024.10.2000DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) SCHWEFELHALTIGE INDIRUBINDERIVATE, DEREN HERSTELLUNG UND VERWENDUNG
(EN) SULPHUR-CONTAINING INDIRUBIN DERIVATIVES, PRODUCTION AND USE THEREOF
(FR) DERIVES D'INDIRUBINE SOUFRES, LEUR PREPARATION ET LEUR UTILISATION
Abstract
(DE)
Es werden Sulfanyl-Indirubinderivate, deren Herstellung und deren Zwischenprodukte zur Herstellung, sowie deren Verwendung als Medikament zur Behandlung von Krebs, wie solide Tumoren und Leukämie, Autoimmunerkrankungen wie Psoriasis, Alopezie und Multiple Sklerose, Chemotherapeutika-induzierte Alopezie und Mukositis, kardiovaskulare Erkrankungen, wie Stenosen, Arteriosklerosen und Restenosen, infektiöse Erkrankungen, wie z. B. durch unizellulare Parasiten, wie Trypanosoma, Toxoplasma oder Plasmodium, oder durch Pilze hervorgerufen, nephrologische Erkrankungen, wie z. B. Glomerulonephritis, chronischen neurodegenerativen Erkrankungen, wie Huntington's Erkrankung, amyotropisch laterale Sklerose, Parkinsonsche Erkrankung, AIDS Dementia und Alzheimer'sche Erkrankung, akuten neurodegenerativen Erkrankungen, wie Ischämien des Gehirns und Neurotraumata, virale Infektionen, wie z. B. Cytomegalus-Infektionen, Herpes, Hepatitis B und C, und HIV Erkrankungen, beschrieben.
(EN)
Sulphonyl indirubin derivatives, the production thereof, the intermediates in the production thereof and the use thereof as a medicament for the treatment of cancer, such as concrete tumours and leukaemias; auto-immune diseases, such as psoriasis, alopecia and multiple sclerosis; chemotherapeutically-induced alopecia and mucositis; cardiovascular diseases, such as stenoses, arterioscleroses and restenoses; infectious diseases such as, for example, caused by uni-cellular parasites such as trypanosoma, toxoplasma or plasmodium, or nephrological diseases caused by fungii such as, for example, glomerulonephritis; chronic neurodegenerative diseases such as Huntington's disease, amyotrophic lateral scleroses, Parkinson's disease, AIDS dementia and Alzheimer's disease; acute neurodegenerative diseases such as cerebral ischaemia and neurological traumas and viral infections, such as for example cytomegalus infections, herpes, hepatitis B and C, and HIV diseases are disclosed.
(FR)
L'invention concerne des dérivés d'indirubine sulfanyle, leur préparation et leurs produits intermédiaires de fabrication, ainsi que leur utilisation comme médicaments pour le traitement de cancers tels que des tumeurs solides et la leucémie, de maladies autoimmunitaires telles que la psoriasis, l'alopécie et la sclérose en plaques, de l'alopécie et de la mucosite induites par chimiothérapie, de maladies cardio-vasculaires telles que les sténoses, les artérioscléroses et les resténoses, de maladies infectieuses comme, par exemple, celles dues à des parasites unicellulaires, telles que le trypanosome, la toxoplasmose ou le plasmodium, ou bien celles provoquées par des champignons, de maladies rénales comme, par exemple, la glomérulonéphrite, de maladies neurodégénératives chroniques telles que la maladie de Huntington, la sclérose latérale amyotrophique, la maladie de Parkinson, la démence du SIDA et la maladie d'Alzheimer, de maladies neurodégénératives aiguës telles que les ischémies cérébrales et les traumatismes neurologiques, d'infections virales comme, par exemple, les infections cytomégaliques, l'herpès, les hépatites B et C, et d'infections par VIH.
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