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1. WO2002034712 - PROCESS FOR PREPARING SUBSTITUTED AROMATIC COMPOUNDS AND INTERMEDIATES THEREFOR

Publication Number WO/2002/034712
Publication Date 02.05.2002
International Application No. PCT/JP2001/009422
International Filing Date 26.10.2001
Chapter 2 Demand Filed 28.11.2001
IPC
C07C 209/58 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
54by rearrangement reactions
58from or via amides
C07C 221/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
221Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
C07C 231/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
08from amides by reaction at nitrogen atoms of carboxamide groups
C07C 231/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
12by reactions not involving the formation of carboxamide groups
C07D 215/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
C07D 215/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
58with hetero atoms directly attached to the ring nitrogen atom
60N-oxides
CPC
C07C 209/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
54by rearrangement reactions
58from or via amides
C07C 221/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
221Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
C07C 231/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
08from amides by reaction at nitrogen atoms of carboxamide groups
C07C 231/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
12by reactions not involving the formation of carboxamide groups
C07D 215/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
C07D 215/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
58with hetero atoms directly attached to the ring nitrogen atom
60N-oxides
Applicants
  • TAKEDA CHEMICAL INDUSTRIES, LTD. [JP]/[JP] (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW)
  • MIZUNO, Masahiro [JP]/[JP] (UsOnly)
  • YAMANO, Mitsuhisa [JP]/[JP] (UsOnly)
Inventors
  • MIZUNO, Masahiro
  • YAMANO, Mitsuhisa
Agents
  • AOYAMA, Tamotsu
Priority Data
2000-32904027.10.2000JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PROCESS FOR PREPARING SUBSTITUTED AROMATIC COMPOUNDS AND INTERMEDIATES THEREFOR
(FR) PROCEDE DE PREPARATION DE COMPOSES AROMATIQUES SUBSTITUES ET PRODUITS INTERMEDIAIRES ASSOCIES
Abstract
(EN)
A process for preparing substituted aromatic compounds of the general formula (||) or salts thereof: (||) [wherein A is an optionally substituted aromatic homo- or hetero-cycle; X is O- or the like; Y is NR1- or the like; and B is an optionally substituted aromatic homo- or hetero-cycle, or optionally substituted ethylene] by subjecting compounds of the general formula (|) or salts thereof: (|) [wherein each symbol is as defined above] to Smiles rearrangement, characterized in that the Smiles rearrangement is conducted in the presence of a basic hydroxide in an amide solvent. According to this process, the problems of Smiles rearrangement can be solved and various aromatic compounds useful as drugs, agricultural chemicals, or intermediates for the production of various general-purpose chemicals can be efficiently prepared by Smiles rearrangement.
(FR)
L'invention concerne un procédé de préparation de composés aromatique substitués de formule générale (I) ou de sels desdits composés. Dans cette formule, A est un homocycle ou un hétérocycle aromatique éventuellement substitué, X est -O- ou analogue, Y est NR1- ou analogue, et B est un homocycle ou un hétérocycle aromatique éventuellement substitué ou un éthylène éventuellement substitué. Ce procédé consiste à soumettre les composés de formule générale (I) ou les sels desdits composés à un réarrangement de Smiles, chaque symbole étant tel que défini ci-dessus. On opère le réarrangement de Smiles en présence d'un hydroxyde basique dans un solvant amidique. Ledit procédé permet de résoudre les problèmes liés au réarrangement de Smiles. On peut ainsi préparer efficacement une pluralité de composés aromatiques par réarrangement de Smiles, lesdits composés pouvant être utilisés comme médicaments, produits chimiques agricoles ou produits intermédiaires destinés à la production de produits chimiques à usages divers.
Also published as
Latest bibliographic data on file with the International Bureau