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1. WO2002034105 - NON-INVASIVE ENDOTHELIAL ACTIVITY EVALUATION

Publication Number WO/2002/034105
Publication Date 02.05.2002
International Application No. PCT/IL2001/000970
International Filing Date 22.10.2001
Chapter 2 Demand Filed 29.05.2002
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 5/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
CPC
A61B 5/02007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
02007Evaluating blood vessel condition, e.g. elasticity, compliance
A61B 5/02241
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
021Measuring pressure in heart or blood vessels
022by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
02233Occluders specially adapted therefor
02241of small dimensions, e.g. adapted to fingers
A61B 5/026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
026Measuring blood flow
A61B 5/6824
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
6801specially adapted to be attached to or worn on the body surface
6813Specially adapted to be attached to a specific body part
6824Arm or wrist
A61B 5/6826
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
6801specially adapted to be attached to or worn on the body surface
6813Specially adapted to be attached to a specific body part
6825Hand
6826Finger
A61B 5/6828
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
6801specially adapted to be attached to or worn on the body surface
6813Specially adapted to be attached to a specific body part
6828Leg
Applicants
  • ITAMAR MEDICAL LTD. [IL]/[IL] (AllExceptUS)
  • SCHNALL, Robert, P. [IL]/[IL] (UsOnly)
  • SHEFFY, Jacob [IL]/[IL] (UsOnly)
  • LAVIE, Peretz [IL]/[IL] (UsOnly)
Inventors
  • SCHNALL, Robert, P.
  • SHEFFY, Jacob
  • LAVIE, Peretz
Agents
  • G. E. EHRLICH (1995) LTD.
Priority Data
60/242,05423.10.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NON-INVASIVE ENDOTHELIAL ACTIVITY EVALUATION
(FR) PROCEDE ET APPAREIL POUR UNE EVALUATION NON INVASIVE DE L'ACTIVITE ENDOTHELIALE D'UN PATIENT
Abstract
(EN)
A method and apparatus non-invasively indicates an endothelial dysfunction condition in a patient. The method includes appying an occluding pressure to a predetermined part of a patient's extremity to occlude arterial blood flow, maintaining the pressure for a predetermined time period, removing the pressure after the elapse off such period to restore arterial blood flow, monitoring a digit of the extremity by a probe for arterial tone changes therein before and after application of the occluding pressure to the extremity, and utilizing detected peripheral arterial tone changes to evaluate endothelial activity in the patient. Important advantages are provided when the occluding cuff (OC) is applied to the same digit receiving the monitoring digit probe (MDP) on the proximal side thereof with respect to the patient's heart, and when a reference probe is applied to another digit, uninfluenced by the occluding pressure, to compensate for shifts inherent to vascular beds.
(FR)
L'invention concerne un procédé et un appareil permettant d'évaluer de manière non invasive l'activité endothéliale d'un patient, et permettant en particulier d'indiquer la présence d'un dysfonctionnement endothélial, en appliquant une pression occlusive sur une partie prédéterminée d'un bras ou d'une jambe du patient, destinée à former une occlusion au niveau du flux du sang artériel; par le maintien de la pression occlusive pendant une période prédéterminée; en relâchant la pression occlusive, une fois la période prédéterminée écoulée, pour rétablir le flux du sang artériel; en surveillant un doigt de la main ou du pied du patient, au moyen une sonde digitale détectant les variations au niveau du tonus artériel périphérique du patient, avant et après la pression occlusive appliquée sur le bras ou la jambe du patient; et en utilisant toute variation détectée au niveau du tonus artériel périphérique pour évaluer l'activité endothéliale du patient. L'invention présente des avantages particulièrement importants lorsque le manchon compressif est appliqué au doigt du patient qui reçoit la sonde digitale de surveillance, sur la partie proximale de celui-ci, par rapport au coeur du patient, et également lorsqu'une sonde digitale de référence est appliquée sur un autre doigt, non influencée par la pression occlusive, afin de compenser les décalages inhérents aux réseaux vasculaires.
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