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1. (WO2002033111) NUCLEIC ACID CONSTRUCTS AND CELLS, AND METHODS UTILIZING SAME FOR MODIFYING THE ELECTROPHYSIOLOGICAL FUNCTION OF EXCITABLE TISSUES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/033111    International Application No.:    PCT/IL2001/000833
Publication Date: 25.04.2002 International Filing Date: 05.09.2001
Chapter 2 Demand Filed:    11.04.2002    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/705 (2006.01)
Applicants: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. [IL/IL]; Gutwirth Science Park, Technion City, 32 000 Haifa (IL) (For All Designated States Except US).
FELD, Yair [IL/IL]; (IL) (For US Only).
GEPSTEIN, Lior [IL/IL]; (IL) (For US Only).
MAROM, Shimon [IL/IL]; (IL) (For US Only).
FRANK, Meira [IL/IL]; (IL) (For US Only)
Inventors: FELD, Yair; (IL).
GEPSTEIN, Lior; (IL).
MAROM, Shimon; (IL).
FRANK, Meira; (IL)
Agent: G. E. EHRLICH (1995) LTD.; 28 Bezalel Street, 52 521 Ramat Gan (IL)
Priority Data:
09/691,889 20.10.2000 US
Title (EN) NUCLEIC ACID CONSTRUCTS AND CELLS, AND METHODS UTILIZING SAME FOR MODIFYING THE ELECTROPHYSIOLOGICAL FUNCTION OF EXCITABLE TISSUES
(FR) CONSTRUCTIONS D'ACIDE NUCLEIQUE ET CELLULES, ET LEURS METHODES D'UTILISATION POUR MODIFIER LA FONCTION ELECTROPHYSIOLOGIQUE DE TISSUS EXCITABLES
Abstract: front page image
(EN)A method of modifying the electrophysiological function of an excitable tissue region of an individual is provided. The method includes the step of implanting cells into the excitable tissue region. Each implanted cell is (a) capable of forming gap junctions with at least one cell of the excitable tissue region; and (b) capable of forming a functional ion channel or transporter, wherein the functional ion channel or transporter is capable of modifying the electrophysiological function of the excitable tissue region.
(FR)L'invention concerne une méthode permettant de modifier la fonction électrophysiologique d'une zone de tissus excitables chez un individu. Cette méthode consiste à implanter des cellules dans ladite zone de tissus excitables. Chaque cellule implantée est (a) capable de former des jonctions lacunaires avec au moins une cellule de la zone de tissus excitables, et (b) capable de former un canal ionique fonctionnel ou un transporteur, ledit canal ionique fonctionnel ou transporteur étant capable de modifier la fonction électrophysiologique de la zone de tissus excitables.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)