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Pub. No.:    WO/2002/033045    International Application No.:    PCT/US2001/042658
Publication Date: 25.04.2002 International Filing Date: 11.10.2001
Chapter 2 Demand Filed:    06.05.2002    
A61K 9/127 (2006.01)
Applicants: THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC. [US/US]; 455 First Avenue, New York, NY 10016 (US) (For All Designated States Except US).
TYAGI, Sanjay [IN/US]; (US) (For US Only).
KRAMER, Fred, R. [US/US]; (US) (For US Only).
ALSMADI, Osama, A. [JO/US]; (US) (For US Only)
Inventors: TYAGI, Sanjay; (US).
KRAMER, Fred, R.; (US).
ALSMADI, Osama, A.; (US)
Agent: HONE, William, J.; Fish & Richardson P.C., Suite 2800, 45 Rockefeller Plaza, New York, NY 10111 (US)
Priority Data:
60/239,698 12.10.2000 US
Abstract: front page image
(EN)Cells, liposomes and lipid particles are provided with complementary projecting oligonucleotides, which hybridize to bring them together as an aid to efficient fusion, which may be further aided by osmotic or electrical shock. The invention further provides complementary pairs of oligonucleotides containing moieties to anchor them in cellular and liposome membranes, as well as liposomes that carry agents to be introduced into cells and that are provided with membrane-bound projecting oligonucleotides.
(FR)Selon l'invention, des cellules, des liposomes et des particules lipidiques sont fournis avec des oligonucléotides dressés complémentaires, qui s'hybrident pour les rassembler en tant qu'auxiliaire pour une fusion efficace, laquelle peut être encore améliorée par un choc osmotique ou électrique. L'invention concerne des paires d'oligonucléotides complémentaires contenant des fragments destinés à les ancrer dans des membranes cellulaires ou liposomales, ainsi que des liposomes qui transportent des agents à introduire dans des cellules, et sont dotés d'oligonucléotides dressés fixés à la membrane.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)