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1. (WO2002032955) HUMAN GENE CRITICAL TO FERTILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/032955    International Application No.:    PCT/US2001/010981
Publication Date: 25.04.2002 International Filing Date: 04.04.2001
Chapter 2 Demand Filed:    09.05.2002    
IPC:
C07K 14/47 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES. [US/US]; The National Institutes of Health, Office of Technology Transfer, 6011 Executive Blvd. Suite # 325, Rockville, MD 20852 (US) (For All Designated States Except US).
NELSON, Lawrence, M. [US/US]; (US) (For US Only).
TONG, Zhi-Bin [CN/US]; (US) (For US Only)
Inventors: NELSON, Lawrence, M.; (US).
TONG, Zhi-Bin; (US)
Agent: HARDING, Tanya, M.; Klarquist, Sparkman, Campbell, Leigh & Whinston, L, LP, One World Trade Center, Suite 1600, 121 SW Salmon Street, Portland, OR 97204 (US).
NOONAN, William, D.; Klarquist, Sparkman, LLP, One World Trade Center, Suite 1600, 121 S.W. Salmon Street, Portland, OR 97204 (US)
Priority Data:
60/241,510 18.10.2000 US
Title (EN) HUMAN GENE CRITICAL TO FERTILITY
(FR) GENE HUMAIN INDISPENSABLE A LA FERTILITE
Abstract: front page image
(EN)Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of fertility and reduced fertility. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
(FR)L'invention concerne un acide nucléique et des séquences protéiniques nouveaux qui sont essentiels pour la fertilité. En particulier, l'invention concerne des séquences d'ADNc Mater humain et protéiniques. Le MATER fonctionnel est nécessaire pour la fertilité féminine; les zygotes qui découlent d'oocytes zéro Mater ne dépassent pas le niveau de deux cellules. L'invention concerne des procédés d'utilisation de molécules Mater dans les diagnostics, pronostics et traitement d'infertilité et de fertilité diminuée. Elle concerne également des procédés d'utilisation de MATER en tant qu'agent de contraception. Elle concerne enfin des composés entrant dans ces procédés et leur identification.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)