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1. (WO2002032917) MACROLIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/032917    International Application No.:    PCT/IB2001/002167
Publication Date: 25.04.2002 International Filing Date: 19.10.2001
Chapter 2 Demand Filed:    14.05.2002    
IPC:
C07H 17/08 (2006.01)
Applicants: GLAXO GROUP LIMITED [BG/BG]; Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 0NN (GB) (For All Designated States Except US).
PLIVA D.D. [HR/HR]; Ulica grada Bukovara 49, Zagreb (HR) (For All Designated States Except US).
ALIHODZIC, Suleman [HR/HR]; (HR) (For US Only).
BERDIK, Andrea [HR/HR]; (HR) (For US Only).
CARDULLO, Francesca [IT/IT]; (IT) (For US Only).
HUTINEC, Antun [HR/HR]; (HR) (For US Only).
LAZAREVSKI, Gorjana [HR/HR]; (HR) (For US Only).
LOCIURO, Sergio [IT/IT]; (IT) (For US Only).
MARUSIC-ISTUK, Zorica [HR/HR]; (HR) (For US Only).
MUTAK, Stjepan [HR/HR]; (HR) (For US Only).
POZZAN, Alfonso [IT/IT]; (IT) (For US Only).
DEREK, Marko [HR/HR]; (HR) (For US Only)
Inventors: ALIHODZIC, Suleman; (HR).
BERDIK, Andrea; (HR).
CARDULLO, Francesca; (IT).
HUTINEC, Antun; (HR).
LAZAREVSKI, Gorjana; (HR).
LOCIURO, Sergio; (IT).
MARUSIC-ISTUK, Zorica; (HR).
MUTAK, Stjepan; (HR).
POZZAN, Alfonso; (IT).
DEREK, Marko; (HR)
Agent: DOLTON, Peter, I.; GlaxoSmithKline, Corporate Intellectual Property, 980 Great West Road, Brentford, Middlesex TW8 9GS (GB)
Priority Data:
0025688.3 19.10.2000 GB
Title (EN) MACROLIDES
(FR) MACROLIDES
Abstract: front page image
(EN)The present invention relates to a compound of formula (I) wherein R¿1? is hydrogen or together with R¿2? is oxo; R¿2? represents hydroxy, OC(O)XR¿7?, OC(O)NHXR¿7? or R¿2? together with R¿1? is an oxo group; R¿3? is hydrogen or a hydroxyl protecting group; R¿4? is hydrogen or XR¿7?; R¿5? is hydrogen, XR¿7? or C(O)NHXR¿7?; R¿6? is hydrogen or R¿5? and R¿6? taken together with the intervening atoms form a cyclic carbonate having the following structure and pharmaceutically acceptable salts and solvates thereof and solvates thereof; to processes for their preparation and their use in the therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.
(FR)La présente invention concerne un composé de la formule (I), dans laquelle R¿1? représente hydrogène ou représente oxo avec R¿2? ; R¿2? représente hydroxy, OC(O)XR¿7?, OC(O)NHXR¿7? ou R¿2? et R¿1? représentent ensemble un groupe oxo ; R¿3? représente hydrogène ou un groupe protecteur hydroxyle ; R¿4? représente hydrogène ou XR¿7? ; R¿5? représente hydrogène, XR¿7?, C(O)XR¿7? ou C(O)NHXR¿7? ; R¿6? représente hydrogène ou R¿5? et R¿6? pris ensemble avec les atomes intermédiaires forment un carbonate cyclique comportant la structure (a), ainsi que des sels et solvates pharmaceutiquement acceptables de ce composé ; l'invention concerne également des procédés pour leur préparation et leur utilisation dans le traitement ou la prophylaxie d'infections bactériennes systémiques ou topiques dans un corps humain ou animal.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)