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Machine translation
1. (WO2002032842) COMPOUNDS WITH HIGH MONOAMINE TRANSPORTER AFFINITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/032842    International Application No.:    PCT/US2001/032575
Publication Date: 25.04.2002 International Filing Date: 17.10.2001
Chapter 2 Demand Filed:    16.05.2002    
IPC:
C07C 43/188 (2006.01), C07D 309/06 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street, Cambridge, MA 02138 (US) (For All Designated States Except US).
ORGANIX, INC. [US/US]; 240 Salem Street, Woburn, MA 01801 (US) (For All Designated States Except US).
METZLER, Peter, C. [US/US]; (US) (For US Only).
BLUNDELL, Paul [US/US]; (US) (For US Only).
WANG, Pinglang [US/US]; (US) (For US Only).
MADRAS, Bertha, K. [US/US]; (US) (For US Only)
Inventors: METZLER, Peter, C.; (US).
BLUNDELL, Paul; (US).
WANG, Pinglang; (US).
MADRAS, Bertha, K.; (US)
Agent: LOWEN, Cara, Z.; Dike, Bronstein, Roberts & Cushman, Intellectual Property Practice Group, Edwards & Angell, P.O. Box 9169, Boston, MA 02209 (US)
Priority Data:
09/691,396 17.10.2000 US
Title (EN) COMPOUNDS WITH HIGH MONOAMINE TRANSPORTER AFFINITY
(FR) COMPOSES A FORTE AFFINITE POUR UN TRANSPORTEUR DE MONOAMINE
Abstract: front page image
(EN)Compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out below in which the variables are as defined in the claims. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat various medical indications including, without limitation, attention deficit hyperactivity disorder (ADHD), Parkinson's disease, cocaine addiction, smoking cessation, weight reduction, obsessive-compulsive disorder, various forms of depression, traumatic brain injury, stroke, and narcolepsy.
(FR)La présente invention concerne des composés qui ont une forte affinité pour un transporteur de monoamine et qui sont représentés par une des deux formules suivantes (I) et (II). Les composés se lient sélectivement ou non sélectivement aux transporteurs de monoamine. Ces composés sont utiles pour traiter diverses pathologies telles que, entre autres, le trouble d'hyperactivité avec déficit de l'attention (THADA), la maladie de Parkinson, la cocaïnomanie, le sevrage du tabac, la perte de poids, les troubles obsessionnels-compulsifs, diverses formes de dépression, les lésions cérébrales traumatiques, l'apoplexie et la narcolepsie.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)