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1. (WO2002032413) A METHOD TO INCORPORATE N-(4-HYDROXYPHENYL) RETINAMIDE IN LIPOSOMES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/032413    International Application No.:    PCT/US2001/032310
Publication Date: 25.04.2002 International Filing Date: 17.10.2001
Chapter 2 Demand Filed:    13.05.2002    
IPC:
A61K 9/127 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 210 W. Seventh Street, Austin, TX 78701 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
LOPEZ-BERESTEIN, Gabriel [US/US]; (US) (For US Only).
TARI, Ana, Maria [PT/US]; (US) (For US Only).
LIM, Soo-Jeong [KR/KR]; (KR) (For US Only)
Inventors: LOPEZ-BERESTEIN, Gabriel; (US).
TARI, Ana, Maria; (US).
LIM, Soo-Jeong; (KR)
Agent: HIGHLANDER, Steven, L.; Fulbright & Jaworski L.L.P., Suite 2400, 600 Congress Avenue, Austin, TX 78701 (US)
Priority Data:
60/241,445 17.10.2000 US
Title (EN) A METHOD TO INCORPORATE N-(4-HYDROXYPHENYL) RETINAMIDE IN LIPOSOMES
(FR) PROCEDE SERVANT A INCORPORER DU N-(4-HYDROXYPHENYL) RETINAMIDE DANS DES LIPOSOMES
Abstract: front page image
(EN)Disclosed herein are simple and unique methods of methods of preparing liposomal compositions of N-(4-hydroxyphenyl) retinamide (4HPR) and/or other retinoids. Also disclosed are liposomal 4HPR compositions prepared by such methods and use of such compositions in the treatment of diseases, such as breast cancer. This invention further provides methods for improving the efficacy of N-(4-hydroxyphenyl) retinamide (4HPR) as a chemopreventive agent in the presence of agents that potentiates its ability increase the expression of inducible nitric oxide synthase (iNOS), and NO production in cells.
(FR)La présente invention concerne des procédés simples et uniques servant à préparer des compositions liposomales de <i>N</i>-(4-hydroxyphényl) rétinamide (4HPR) et/ou d'autres rétinoïdes. Cette invention concerne également des compositions liposomales de 4HPR préparées grâce auxdits procédés, ainsi que l'utilisation desdites compositions dans le cadre du traitement de maladies telles que le cancer du sein. L'invention a également pour objet des procédés servant à améliorer l'efficacité de <i>N</i>-(4-hydroxyphényl) rétinamide (4HPR) en tant qu'agent chimio-préventif en la présence d'agents qui potentialisent son aptitude à augmenter l'expression de l'oxyde nitrique synthase inductible (iNOS), et la production de NO dans les cellules.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)