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1. (WO2002032400) LIPOSOMAL FORMULATION OF MITOXANTRONE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/032400    International Application No.:    PCT/US2001/042757
Publication Date: 25.04.2002 International Filing Date: 16.10.2001
Chapter 2 Demand Filed:    10.05.2002    
IPC:
A61K 9/127 (2006.01), A61K 31/136 (2006.01), A61K 45/06 (2006.01)
Applicants: NEOPHARM, INC. [US/US]; Suite 195 150 Field Drive Lake Forest, Il 60045 (US) (For All Designated States Except US).
AHMAD, Imran [US/US]; (US) (For US Only).
RAHMAN, Aquilur [US/US]; (US) (For US Only)
Inventors: AHMAD, Imran; (US).
RAHMAN, Aquilur; (US)
Agent: GOULD, Robert, M.; Leydig, Voit & Mayer, Ltd. Two Prudential Plaza, Suite 4900 180 North Stetson Chicago, IL 60601-6780 (US)
Priority Data:
60/241,069 16.10.2000 US
Title (EN) LIPOSOMAL FORMULATION OF MITOXANTRONE
(FR) PREPARATION LIPOSOMALES A BASE DE MITOXANTRONE
Abstract: front page image
(EN)This invention pertains to liposomal formulations of mitoxantroneand methods for their manufacture and use. The compositions of the present invention include liposomal formulations of mitoxantrone in which the liposome contains any of a variety of neutral or charged liposome-forming materials in addition to a compound that is thought to bind mitoxantrone, such as cardiolipin. The liposomal compositions can be used advantageously in conjunction with secondary therapeutic agents other than mitoxantrone, including antineoplastic, antifungal, antibiotic among other active agents. Methods are provided in which a therapeutically effective amount of the formulation is administered to a mammal, such as a human.
(FR)Cette invention concerne des préparations liposomales à base de mitoxantrone et des méthodes de production et d'utilisation de ces préparations. Les compositions de l'invention comprennent des préparations liposomales à base de mitoxantrone dans lesquelles le liposome contient l'une quelconque d'une gamme de matières de formation de liposome neutres ou chargées en plus d'un composé réputé se lier à la mitoxantrone, tel que la cardiolipine. Les compositions liposomales de l'invention peuvent être utilisées avantageusement en combinaison avec des agents thérapeutiques secondaires autres que la mitoxantrone, y compris des agents antinéoplastiques, antifongiques, antibiotiques, entre autres agents actifs. L'invention concerne en outre des méthodes grâce auxquelles une quantité thérapeutiquement effective de la préparation est administrée à un mammifère, tel qu'un être humain.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)