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1. (WO2002031507) NON-INVASIVE ENZYME SCREEN FOR TISSUE REMODELLING-ASSOCIATED CONDITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/031507    International Application No.:    PCT/US2001/031980
Publication Date: 18.04.2002 International Filing Date: 15.10.2001
Chapter 2 Demand Filed:    13.05.2002    
IPC:
C12Q 1/37 (2006.01), G01N 33/573 (2006.01), G01N 33/574 (2006.01)
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 300 Longwood Avenue, Boston, MA 02115 (US) (For All Designated States Except US).
MOSES, Marsha, A. [US/US]; (US) (For US Only).
YAN, Li [CI/US]; (US) (For US Only)
Inventors: MOSES, Marsha, A.; (US).
YAN, Li; (US)
Agent: HANLEY, Elizabeth, A.; Lahive & Cockfield, LLP, 28 State Street, Boston, MA 02109 (US)
Priority Data:
60/240,489 13.10.2000 US
Title (EN) NON-INVASIVE ENZYME SCREEN FOR TISSUE REMODELLING-ASSOCIATED CONDITIONS
(FR) ANALYSE ENZYMATIQUE NON INVASIVE D'ETATS ASSOCIES AU REMODELAGE D'UN TISSU
Abstract: front page image
(EN)methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular weight enzyme complexes comprising MMPs.
(FR)L'invention concerne des méthodes et des kits permettant de diagnostiquer la présence et de pronostiquer l'apparition d'états associés au remodelage d'un tissu, qui impliquent le présence de complexes enzymatiques dans un échantillon biologique. Ces méthodes consistent, en particulier, à diagnostiquer la présence ou à pronostiquer l'apparition d'un cancer métastatique par identification de complexes enzymatiques de poids moléculaire élevé comprenant des métalloprotéinases matricielles.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)