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Machine translation
1. (WO2002030910) (2S)-2-(ADAMANTAN-1-YLMETHOXYCARBONYLAMINO)-3-(4-(2-(1,4,5,6-TETRAHYDROPYRIMIDIN-2-YLCARBAMOYL)ETHYL)BENZOYLAMINO)PROPIONIC ACID ISOPROPYL ESTER, ITS PREPARATION AND ITS USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/030910    International Application No.:    PCT/EP2001/011186
Publication Date: 18.04.2002 International Filing Date: 27.09.2001
Chapter 2 Demand Filed:    06.05.2002    
IPC:
C07D 239/16 (2006.01)
Applicants: AVENTIS PHARMA DEUTSCHLAND GMBH [DE/DE]; Brüningstrasse 50, 65929 Frankfurt (DE) (For All Designated States Except US).
GENENTECH INC. [US/US]; 1 DNA Way, South San Francisco, CA 94080-4990 (US) (For All Designated States Except US).
PEYMAN, Anuschirwan [DE/DE]; (DE) (For US Only).
WOLLMANN, Theodor [DE/DE]; (DE) (For US Only).
BREIPOHL, Gerhard [DE/DE]; (DE) (For US Only).
GOURVEST, Jean-François [FR/FR]; (FR) (For US Only).
RUXER, Jean-Marie [FR/FR]; (FR) (For US Only).
GADEK, Thomas, R. [US/US]; (US) (For US Only).
MCDOWELL, Robert [US/US]; (US) (For US Only)
Inventors: PEYMAN, Anuschirwan; (DE).
WOLLMANN, Theodor; (DE).
BREIPOHL, Gerhard; (DE).
GOURVEST, Jean-François; (FR).
RUXER, Jean-Marie; (FR).
GADEK, Thomas, R.; (US).
MCDOWELL, Robert; (US)
Agent: ROUSSEAU, Pierrick; Aventis Pharma S.A., 102, route de Noisy, F-93235 Romainville Cedex (FR)
Priority Data:
00121986.4 10.10.2000 EP
Title (EN) (2S)-2-(ADAMANTAN-1-YLMETHOXYCARBONYLAMINO)-3-(4-(2-(1,4,5,6-TETRAHYDROPYRIMIDIN-2-YLCARBAMOYL)ETHYL)BENZOYLAMINO)PROPIONIC ACID ISOPROPYL ESTER, ITS PREPARATION AND ITS USE
(FR) ESTER ISOPROPYLIQUE DE L'ACIDE PROPIONIQUE (2S)-2-(ADAMANTANE-1-YLMETHOXYCARBONYLAMINO)-3-(4-(2-(1,4,5,6-TETRAYDROPYRIMIDINE-2-YLCARBAMOYL)ETHYL)BENZOYLAMINO), SA PREPARATION ET SON UTILISATION
Abstract: front page image
(EN)The present invention relates to (2S)-2-(adamantan-1-ylmethoxycarbonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)ethyl)benzoylamino)propionic acid isopropyl ester of formula (I) and its physiologically tolerable salts, their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them. The compound of the formula (I) and its physiologically tolerable salts are valuable pharmacologically active compounds which can be used, for example, in the treatment or prophylaxis of diseases which can be influenced by inhibiting the vitronectin receptor, for example of bone diseases such as osteoporosis.
(FR)L'invention concerne l'ester isopropylique de l'acide propionique (2S)-2-(adamantane-1-ylméthoxycarbonylamino)-3-(4-(2-(1,4,5,6-tétraydropyrimidine-2-ylcarbamoyl)éthyl)benzoylamino) de la formule I, ses sels physiologiquement tolérables, leur préparation et leur utilisation comme produits pharmaceutiques, ainsi que les compositions pharmaceutiques les renfermant. Le composé de la formule I et ses sels physiologiquement tolérables sont de précieux composés pharmacologiquement actifs qui peuvent être utilisés, par exemple, pour traiter ou prévenir des maladies pouvant être influencées par l'inhibition du récepteur de vitronectine, par exemple les maladies osseuses telles que l'ostéoporose.
Designated States: AE, AG, AL, AU, BA, BB, BG, BR, BZ, CA, CN, CO, CR, CU, CZ, DM, DZ, EC, EE, GD, GE, HR, HU, ID, IL, IN, IS, JP, KP, KR, LC, LK, LR, LT, LV, MA, MG, MK, MN, MX, NO, NZ, PH, PL, RO, SG, SI, SK, TT, UA, US, UZ, VN, YU, ZA.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)