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Machine translation
1. (WO2002030879) CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/030879    International Application No.:    PCT/GB2001/004326
Publication Date: 18.04.2002 International Filing Date: 27.09.2001
Chapter 2 Demand Filed:    26.04.2002    
IPC:
C07C 311/06 (2006.01), C07C 311/13 (2006.01), C07C 311/16 (2006.01), C07C 311/19 (2006.01), C07C 311/21 (2006.01), C07C 311/29 (2006.01), C07D 209/88 (2006.01), C07D 213/40 (2006.01), C07D 213/42 (2006.01), C07D 213/65 (2006.01), C07D 213/71 (2006.01), C07D 307/52 (2006.01), C07D 317/58 (2006.01)
Applicants: PROLIFIX LIMITED [GB/GB]; 91 Milton Park, Abingdon, Oxfordshire OX14 4RY (GB) (For All Designated States Except US).
WATKINS, Clare, J. [GB/GB]; (GB) (For US Only).
ROMERO-MARTIN, Maria-Rosario [ES/GB]; (GB) (For US Only).
MOORE, Kathryn, G. [GB/GB]; (GB) (For US Only).
RITCHIE, James [GB/GB]; (GB) (For US Only).
FINN, Paul, W. [GB/GB]; (GB) (For US Only).
KALVINSH, Ivars [LV/LV]; (LV) (For US Only).
LOZA, Einars [LV/LV]; (LV) (For US Only).
DIKOVSKA, Klara [LV/LV]; (LV) (For US Only).
GAILITE, Vija [LV/LV]; (LV) (For US Only).
VORONA, Maxim [LV/LV]; (LV) (For US Only).
PISKUNOVA, Irina [LV/LV]; (LV) (For US Only).
STARCHENKOV, Igor [--/LV]; (LV) (For US Only).
ADRIANOV, Victor [--/LV]; (LV) (For US Only).
HARRIS, C., John [GB/GB]; (GB) (For US Only).
DUFFY, James, E., S. [GB/GB]; (GB) (For US Only)
Inventors: WATKINS, Clare, J.; (GB).
ROMERO-MARTIN, Maria-Rosario; (GB).
MOORE, Kathryn, G.; (GB).
RITCHIE, James; (GB).
FINN, Paul, W.; (GB).
KALVINSH, Ivars; (LV).
LOZA, Einars; (LV).
DIKOVSKA, Klara; (LV).
GAILITE, Vija; (LV).
VORONA, Maxim; (LV).
PISKUNOVA, Irina; (LV).
STARCHENKOV, Igor; (LV).
ADRIANOV, Victor; (LV).
HARRIS, C., John; (GB).
DUFFY, James, E., S.; (GB)
Agent: ARMITAGE, Ian, M.; Mewburn Ellis, York House, 23 Kingsway, London, Greater London WC2B 6HP (GB).
ADRIAN H. BRASNETT and others Mewburn Ellis; York House, 23 Kingsway, London WC2B 6HP (GB)
Priority Data:
0023986.3 29.09.2000 GB
60/297,784 14.06.2001 US
60/308,136 30.07.2001 US
Title (EN) CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS
(FR) COMPOSES D'ACIDE CARBAMIQUE COMPRENANT UNE LIAISON SULFONAMIDE EN TANT QU'INHIBITEURS DE HDAC
Abstract: front page image
(EN)This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: -S(=O)2NR1- and -NR1S(=O)2-; R1 is a sulfonamido substituent; and, Q2 is an acid leader group; with the proviso that if J is -S(=O)2NR1-, then Q1 is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
(FR)La présente invention concerne certains composés actifs d'acide carbamique inhibiteurs de l'activité histone diacétylase (HDAC) et correspondant à la formule (I), dans laquelle: A est un groupe aryle; Q?1¿ est une liaison covalente ou un groupe aryle de tête; J est une liaison sulfonamide choisie parmi: -S(=O)¿2?NR?1¿- et -NR?1¿S(=O)¿2?-; R?1¿ est une substituant sulfonamide; et Q?2¿ est un groupe acide de tête; et des sels pharmaceutiquement acceptables, des solvates, des amides, des esters, des éthers, des formes chimiquement protégées, et des prodrogues de ceux-ci. La présente invention concerne également des compositions pharmaceutiques comprenant de tels composés, et l'utilisation de tels composés et compositions, in vitro ainsi que in vivo, pour inhiber des pathologies proliférantes, tel que le cancer et le psoriasis.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)