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Machine translation
1. (WO2002030470) METHODS AND COMPOSITIONS FOR NUCLEIC ACID DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/030470    International Application No.:    PCT/US2001/032274
Publication Date: 18.04.2002 International Filing Date: 15.10.2001
Chapter 2 Demand Filed:    13.05.2002    
IPC:
A61K 48/00 (2006.01)
Applicants: JOHNS HOPKINS UNIVERSITY [US/US]; Suite 906, 111 Market Place, Baltimore, MD 21202 (US) (For All Designated States Except US).
DONAHUE, J., Kevin [US/US]; (US) (For US Only).
MARBAN, Eduardo [US/US]; (US) (For US Only).
NAGATA, Koichi [JP/JP]; (JP) (For US Only).
LAWRENCE, John, H. [US/US]; (US) (For US Only)
Inventors: DONAHUE, J., Kevin; (US).
MARBAN, Eduardo; (US).
NAGATA, Koichi; (JP).
LAWRENCE, John, H.; (US)
Agent: CORLESS, Peter, F.; Edwards & Angell, LLP, Dike, Bronstein, Roberts & Cushman, Intellectual Property Group, P.O. Box 9169, Boston, MA 02209 (US)
Priority Data:
60/240,231 13.10.2000 US
Title (EN) METHODS AND COMPOSITIONS FOR NUCLEIC ACID DELIVERY
(FR) PROCEDES ET COMPOSITIONS PERMETTANT LA DIFFUSION D'ACIDE NUCLEIQUE
Abstract: front page image
(EN)The present provides methods and compositions that enable effective delivery of nucleic to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.
(FR)L'invention concerne des procédés et des compositions permettant de diffuser efficacement un acide nucléique aux cellules souhaitées et également à un organe solide comme un coeur de mammifère. Ces procédés et compositions permettent un transfert de gène efficace et l'expression subséquente d'une majorité de cellules dans un organe solide comme le coeur. Les procédés et compositions de la présente invention permettent d'obtenir une meilleure perméabilité vasculaire qui autorise un transfert de gène accru vers des cellules cibles, sans toutefois causer de dégradation ou de blessure importante aux couches cellulaires endothéliales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)