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Machine translation
1. (WO2002030459) USE OF CD28-SPECIFIC MONOCLONAL ANTIBODIES FOR STIMULATING BLOOD CELLS THAT LACK CD28
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/030459    International Application No.:    PCT/DE2001/003802
Publication Date: 18.04.2002 International Filing Date: 28.09.2001
Chapter 2 Demand Filed:    18.04.2002    
IPC:
C07K 16/28 (2006.01)
Applicants: TEGENERO GMBH [DE/DE]; Mittlere Heerbergstrasse 26, 97078 Würzburg (DE) (For All Designated States Except US).
HÜNIG, Thomas [DE/DE]; (DE) (For US Only).
RODRIGUEZ-PALMERO, Marta [ES/DE]; (DE) (For US Only).
KERKAU, Thomas [DE/DE]; (DE) (For US Only)
Inventors: HÜNIG, Thomas; (DE).
RODRIGUEZ-PALMERO, Marta; (DE).
KERKAU, Thomas; (DE)
Agent: JUNGBLUT, Bernhard; Albrecht, Lüke & Jungblut, Gelferstrasse 56, 14195 Berlin (DE)
Priority Data:
100 50 935.5 11.10.2000 DE
Title (DE) VERWENDUNG CD28 SPEZIFISCHER MONOKLONALER ANTIKÖRPER ZUR STIMULATION VON BLUTZELLEN, WELCHE KEIN CD28 TRAGEN
(EN) USE OF CD28-SPECIFIC MONOCLONAL ANTIBODIES FOR STIMULATING BLOOD CELLS THAT LACK CD28
(FR) UTILISATION D"ANTICORPS MONOCLONAUX SPECIFIQUES A LA MOLECULE CD28 EN VUE DE STIMULER DES CELLULES SANGUINES QUI NE PORTENT AUCUNE MOLECULE CD28
Abstract: front page image
(DE)Die Erfindung lehrt die Verwendung monoklonaler Antikörper, welche für CD28 spezifisch sind und T-Lymphozyten mehrerer bis aller Untergruppen ohne Besetzung eines Antigenrezeptors der T-Lymphozyten und somit antigenunspezifisch aktivieren, oder eines Analogen hierzu zur Herstellung einer pharmazeutischen Zusammensetzung zur Stimulation von Blutzellen, welche kein CD28 tragen bzw. zur Behandlung von Erkrankungen mit reduzierter Anzahl solcher Blutzellen.
(EN)The invention relates to the use of monoclonal antibodies that are specific of CD28 and that activate the T lymphocytes of several to all subtypes without occupying an antigen receptor of the T lymphocytes, thereby activating the T lymphocytes in an antigen-unspecific manner. The invention also relates to an analog thereof for producing a pharmaceutical preparation for stimulating blood cells that lack CD28, or for treating diseases that are characterized by a reduced number of such blood cells.
(FR)La présente invention concerne l"utilisation d"anticorps monoclonaux spécifiques à la molécule CD28 ou d"un analogue de ceux-ci, qui activent des lymphocytes T de plusieurs sous-groupes ou de tous les sous-groupes, sans occuper de récepteur d"antigène des lymphocytes T, donc de manière non spécifique aux antigènes, en vue de produire une composition pharmaceutique permettant la stimulation de cellules sanguines qui ne portent aucune molécule CD28 ou permettant le traitement de maladies qui induisent un nombre réduit de ces cellules sanguines.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)