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1. (WO2002029403) GATA-3 EXPRESSION INHIBITOR AND METHOD OF SCREENING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/029403    International Application No.:    PCT/JP2001/008564
Publication Date: 11.04.2002 International Filing Date: 28.09.2001
Chapter 2 Demand Filed:    11.04.2002    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/47 (2006.01)
Applicants: MOCHIDA PHARMACEUTICAL CO., LTD. [JP/JP]; 7, Yotsuya 1-chome Shinjuku-ku, Tokyo 160-8515 (JP) (For All Designated States Except US).
FURUSAKO, Shoji [JP/JP]; (JP) (For US Only).
KATO, Yutaka [JP/JP]; (JP) (For US Only).
NEGISHI, Takaaki [JP/JP]; (JP) (For US Only)
Inventors: FURUSAKO, Shoji; (JP).
KATO, Yutaka; (JP).
NEGISHI, Takaaki; (JP)
Agent: WATANABE, Mochitoshi; Hayakawa-tonakai Bldg. 3F 12-5, Iwamoto-cho 2-chome Chiyoda-ku, Tokyo 101-0032 (JP)
Priority Data:
2000-302779 02.10.2000 JP
Title (EN) GATA-3 EXPRESSION INHIBITOR AND METHOD OF SCREENING THE SAME
(FR) INHIBITEUR DE L'EXPRESSION DE GATA-3 ET PROCEDE DE DEPISTAGE DUDIT INHIBITEUR
Abstract: front page image
(EN)A method of efficiently finding out a substance inhibiting the Th2 shift of helper T cells mediated by binding to AhR, a substance acting on the IgE class switch of B cells to thereby inhibit the IgE production from B cells and/or a substance inhibiting an inflammatory reaction accompanied by the differentiation/migration or infiltration of eosinophils, and a substance modifying the expression of GATA-3 of T cells; and a GATA-3 expression inhibitor.
(FR)L'invention concerne un procédé pour découvrir efficacement une substance inhibant la déviation vers Th2 de lymphocytes T auxiliaires à médiation par liaison au récepteur arylhydrocarbone (AhR), une substance agissant sur la commutation isotypique des IgE de cellules B pour inhiber la production d'IgE de cellules B et/ou une substance inhibant une réaction inflammatoire accompagnée d'une différenciation/migration ou infiltration d'éosinophiles et une substance modifiant l'expression de GATA-3 de cellules T. L'invention concerne également un inhibiteur de l'expression de GATA-3.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)