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1. (WO2002029090) SUBSANCE INHIBITING THE BINDING OF SIGNAL TRANSDUCING MOLECULE TO KDR/FLK-1 PHOSPHORYLATED AT TYROSINE AT THE 1175-POSITION AND METHOD OF USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/029090    International Application No.:    PCT/JP2001/008684
Publication Date: 11.04.2002 International Filing Date: 02.10.2001
Chapter 2 Demand Filed:    02.04.2002    
IPC:
C07K 16/28 (2006.01), C12Q 1/48 (2006.01)
Applicants: KYOWA HAKKO KOGYO CO., LTD. [JP/JP]; 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100-8185 (JP).
SHIBUYA, Masabumi [JP/JP]; (JP)
Inventors: SHIBUYA, Masabumi; (JP).
TAKAHASHI, Tomoko; (JP).
FURUYA, Akiko; (JP).
SHITARA, Kenya; (JP)
Agent: OGURI, Shohei; Eikoh Patent Office 28th Floor, ARK Mori Building 12-32, Akasaka 1-chome Minato-ku, Tokyo 107-6028 (JP)
Priority Data:
2000-303694 03.10.2000 JP
Title (EN) SUBSANCE INHIBITING THE BINDING OF SIGNAL TRANSDUCING MOLECULE TO KDR/FLK-1 PHOSPHORYLATED AT TYROSINE AT THE 1175-POSITION AND METHOD OF USING THE SAME
(FR) SUBSTANCE INHIBANT LA FIXATION DE LA MOLECULE DE TRANSDUCTION DE SIGNAL AU RECEPTEUR KDR/FLK-1 PHOSPHORYLE AU NIVEAU DE LA TYROSINE A LA POSITION 1175 ET TECHNIQUE D'UTILISATION
Abstract: front page image
(EN)A substance blocking the intracellular signal transduction of KDR/Flk-1 and inhibits cell proliferation by VEGF; a method of inhibiting the signal transduction of KDR/Flk-1 by using this substance; a method of inhibiting cell proliferation by using the same; a method of inhibiting angiogenesis by using the same; a method of screening a cell proliferation inhibitor by using the same; a method of screening an angiogenesis inhibitor by using the same; a method of screening a substance inhibiting the signal transduction of KDR/Flk-1 by using the same; a method of judging whether or not a test substance inhibits the signal transduction of KDR/Flk-1 by using the same; and a method of screening a substance inhibiting the phosphorylation at tyrosine at the 1175-position of KDR/Flk-1 by using the same.
(FR)La présente invention concerne une substance qui bloque la transduction du signal intracellulaire du récepteur KDR/Flk-1 et qui inhibe la prolifération cellulaire par le facteur de croissance VEGF. Cette invention concerne aussi l'utilisation de cette substance dans les techniques suivantes: inhibition du signal de transduction du récepteur KDR/Flk-1, inhibition de la prolifération cellulaire, inhibition de l'angiogenèse, criblage d'inhibiteur de la prolifération cellulaire, criblage d'inhibiteur d'angiogenèse, criblage de substance inhibant le signal de transduction du récepteur KDR/Flk-1, estimation de l'activité inhibitrice d'une substance d'essai sur le signal de transduction du récepteur KDR/Flk-1, et criblage d'une substance inhibant la phosphorylation au niveau de la tyrosine à la position 1175 du récepteur KDR/Flk-1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)