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Machine translation
1. (WO2002029001) NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/029001    International Application No.:    PCT/US2001/030936
Publication Date: 11.04.2002 International Filing Date: 03.10.2001
Chapter 2 Demand Filed:    12.04.2002    
IPC:
C07F 9/09 (2006.01), C07F 9/38 (2006.01), C07F 9/572 (2006.01), C07F 9/6506 (2006.01), C07F 9/655 (2006.01), C07K 14/705 (2006.01)
Applicants: UNIVERSITY OF VIRGINIAN PATENT FOUNDATION [US/US]; 1224 West Main Street, Suites 1-110, Charlottesville, VA 22903 (US) (For All Designated States Except US).
LYNCH, Kevin, R. [US/US]; (US) (For US Only).
MACDONALD, Timothy, L. [US/US]; (US) (For US Only).
HEISE, Christopher, E. [US/US]; (US) (For US Only).
SANTOS, Webster, L. [US/US]; (US) (For US Only).
OKUSA, Mark, D. [US/US]; (US) (For US Only)
Inventors: LYNCH, Kevin, R.; (US).
MACDONALD, Timothy, L.; (US).
HEISE, Christopher, E.; (US).
SANTOS, Webster, L.; (US).
OKUSA, Mark, D.; (US)
Agent: BREEN, John, P.; University of Virginia Patent Foundation, 1224 West Main Street, Suite 1-110, Charlottesville, VA 22903 (US)
Priority Data:
60/237,436 03.10.2000 US
60/264,046 25.01.2001 US
60/297,507 13.06.2001 US
Title (EN) NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS
(FR) NOUVEAUX AGONISTES ET ANTAGONISTES DES RECEPTEURS DE L'ACIDE LYSOPHOSPHATIDIQUE
Abstract: front page image
(EN)The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.
(FR)L'invention concerne des compositions contenant des analogues de l'acide lysophosphatidique (LPA) et des procédés d'utilisation de ces analogues comme agonistes ou antagonistes de l'activité des récepteurs de LPA. De plus, l'invention a trait à des agonistes des récepteurs de LPA dont le degré de sélectivité varie selon les récepteurs de LPA individuels (c.-à-d. LPA1, LPA2 et LPA3). L'invention concerne plus particulièrement des analogues de LPA dans lesquels le glycérol est remplacé par de l'éthanolamine et diverses substitutions ont été liées au deuxième atome de carbone.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)