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Machine translation
1. (WO2002028886) CALOXINS THEIR ISOLATION AND USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/028886    International Application No.:    PCT/CA2001/001409
Publication Date: 11.04.2002 International Filing Date: 05.10.2001
Chapter 2 Demand Filed:    02.05.2002    
IPC:
A61K 38/00 (2006.01), C07K 7/06 (2006.01), C07K 7/08 (2006.01)
Applicants: MCMASTER UNIVERSITY [CA/CA]; 1200 Main Street West, Health Science Centre, Room 3N43, Hamilton, Ontario L8N 3Z5 (CA).
GROVER, Ashok, K. [CA/CA]; (CA) (For US Only).
ESCHER, Emanuel [CA/CA]; (CA) (For US Only).
CHAUDHARY, Jyoti [IN/CA]; (CA) (For US Only)
Inventors: GROVER, Ashok, K.; (CA).
ESCHER, Emanuel; (CA).
CHAUDHARY, Jyoti; (CA)
Agent: BERESKIN & PARR; 40 King Street West, Box 401, 40th Floor, Toronto, Ontario M5H 3Y2 (CA)
Priority Data:
60/237,702 05.10.2000 US
Title (EN) CALOXINS THEIR ISOLATION AND USE
(FR) CALOXINES
Abstract: front page image
(EN)Novel compound called caloxins which are extracellular plasma membrane (PM) Ca?2+¿-pump inhibitors are described. One caloxin is caloxin 2A1 and has the amino acid sequence VSNSNWPSFPSSGGG. Another caloxin is caloxin 3A1 and has the amino acid sequence DSHINNEPSRRRGGGK. The caloxins are useful in inhibiting PM Ca?2+¿-pumps and can be used in the development of treatments of various diseases including hypertension, hypotension, degenerative brain disorders, mood disorders, diabetes, kidney failure and cancer.
(FR)L'invention concerne de nouveaux composés appelés caloxines (caloxin) qui sont des inhibiteurs de la pompe Ca?2+ ¿extracellulaire (PM). Une première caloxine est la caloxine 2A1 présentant la séquence d'acides aminés: « SNSNWPSFPSSGGG ». Une autre caloxine est la caloxine 3A1 présentant la séquence d'acides aminés: « DSHINNEPSRRRGGGK ». On utilise ces caloxines pour inhiber les pompes Ca?2+¿ PM ainsi que dans l'élaboration de traitements contre diverses maladies, notamment l'hypertension, l'hypotension, les troubles de dégénérescence cérébrale, les troubles de l'humeur, le diabète, l'agénésie rénale et le cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)