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Pub. No.:    WO/2002/028859    International Application No.:    PCT/US2001/042173
Publication Date: 11.04.2002 International Filing Date: 17.09.2001
Chapter 2 Demand Filed:    15.04.2002    
C07D 471/14 (2006.01)
Applicants: LILLY ICOS LLC [US/US]; 1209 Orange Street, Wilmington, DE 19801 (US) (For All Designated States Except US).
ORME, Mark, W. [US/US]; (US) (For US Only).
SAWYER, Jason, Scott [US/US]; (US) (For US Only).
DAUGAN, Alain, Claude-Marie [FR/FR]; (FR) (For US Only).
GELLIBERT, Françoise [FR/FR]; (FR) (For US Only).
GOSMINI, Romain, Luc, Marie [FR/FR]; (FR) (For US Only)
Inventors: ORME, Mark, W.; (US).
SAWYER, Jason, Scott; (US).
DAUGAN, Alain, Claude-Marie; (FR).
GELLIBERT, Françoise; (FR).
GOSMINI, Romain, Luc, Marie; (FR)
Agent: NAPOLI, James, J.; Marshall, Gerstein & Borun, 6300 Sears Tower, 233 South Wacker Drive, Chicago, IL 60606 (US)
Priority Data:
60/237,240 02.10.2000 US
Abstract: front page image
(EN)Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents. In particular, the invention relates to compounds that, are potent and selective inhibitors of cyclic guanosine 3', 5'-monophosphate specific phosphodiesterase (cGMP-specific PDE), in particular PDE5, ad have utility in a variety of therapeutic areas wherein such inhibition is considered beneficial, including the treatment of cardiovascular disorders and erectile dysfunction.
(FR)Cette invention, qui a trait à des composés correspondant à la formule générale de structure (I), concerne également l'utilisation de ces composés, de leurs sels et de leurs solvates en tant qu'agents thérapeutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)