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1. (WO2002028835) BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/028835    International Application No.:    PCT/JP2001/008581
Publication Date: 11.04.2002 International Filing Date: 28.09.2001
Chapter 2 Demand Filed:    02.05.2002    
IPC:
C07D 213/30 (2006.01), C07D 213/38 (2006.01), C07D 213/40 (2006.01), C07D 213/56 (2006.01), C07D 213/73 (2006.01), C07D 213/81 (2006.01), C07D 277/28 (2006.01), C07D 277/30 (2006.01), C07D 277/40 (2006.01)
Applicants: FUJISAWA PHARMACEUTICAL CO., LTD. [JP/JP]; 4-7, Doshomachi 3-chome, Chuo-ku Osaka-shi, Osaka 541-8514 (JP) (For All Designated States Except US).
DAISO CO., LTD. [JP/JP]; 10-8, Edobori 1-chome, Nishi-ku Osaka-shi, Osaka 550-0002 (JP) (For All Designated States Except US).
TAKASUGI, Hisashi [JP/JP]; (JP) (For US Only).
TERASAWA, Takeshi [JP/JP]; (JP) (For US Only).
INOUE, Yoshikazu [JP/JP]; (JP) (For US Only).
NAKAMURA, Hideko [JP/JP]; (JP) (For US Only).
NAGAYOSHI, Akira [JP/JP]; (JP) (For US Only).
OHTAKE, Hiroaki [JP/JP]; (JP) (For US Only).
FURUKAWA, Yoshiro [JP/JP]; (JP) (For US Only).
MIKAMI, Masafumi [JP/JP]; (JP) (For US Only).
HINOUE, Kazumasa [JP/JP]; (JP) (For US Only).
OHTSUBO, Makoto [JP/JP]; (JP) (For US Only)
Inventors: TAKASUGI, Hisashi; (JP).
TERASAWA, Takeshi; (JP).
INOUE, Yoshikazu; (JP).
NAKAMURA, Hideko; (JP).
NAGAYOSHI, Akira; (JP).
OHTAKE, Hiroaki; (JP).
FURUKAWA, Yoshiro; (JP).
MIKAMI, Masafumi; (JP).
HINOUE, Kazumasa; (JP).
OHTSUBO, Makoto; (JP)
Agent: TAKASHIMA, Hajime; Fujimura Yamato Seimei Bldg. 2-14, Fushimimachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0044 (JP)
Priority Data:
PR0583 05.10.2000 AU
PR6666 27.07.2001 AU
Title (EN) BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS
(FR) COMPOSÉS À BASE DE BENZAMIDE, INHIBITEURS DES SÉCRÉTIONS D'APOLIPOPROTÉINE B
Abstract: front page image
(EN)The present invention relates to compounds of the formula (I) wherein R¿1? and R¿2? are each independently lower alkyl, lower alkenyl, acyl, amino, lower alkoxy, lower cycloalkyloxy, aryl, aryloxy, sulfooxy, mercapto, sulfo, hydrogen, halogen, nitro, cyano or hydroxy, or may form a ring structure; Q?1¿ is N or CH; L is optionally substituted unsaturated 3 to 10-membered heterocyclic group; X is optionally substituted monocyclic arylene or monocyclic heteroarylene; Y is -(A?1¿)¿m?-(A?2¿)¿n?-(A?4¿)¿k?-; Z is direct bond, -CH2-, -NH- or -O-; and R is hydrogen or lower alkyl, or a salt thereof. The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.
(FR)La présente invention concerne des composés représentés par la formule (I). Dans cette formule, R¿1? et R¿2? sont chacun indépendamment alkyle inférieur, alcényle inférieur, acyle, amino, alcoxy inférieur, cycloalkyloxy inférieur, aryle, aryloxy, sulfooxy, mercapto, sulfo, hydrogène, halogène, nitro, cyano ou hydroxy, ou peuvent former une structure cyclique. Q?1¿ est N ou CH. L est un groupe hétérocyclique de 3 à 10 membres, saturé, éventuellement substitué. X est arylène ou hétéroarylène monocyclique éventuellement substitué. Y est -(A?1¿)¿m?-(A?2¿)¿n?-(A?4¿)¿k?-. Z est liaison directe, -CH2-, -NH- ou -O-. Enfin, R est hydrogène ou alkyle inférieur, ou l'un de ses sels. Les composés de la présente invention, qui sont des inhibiteurs de la sécrétion d'apolipoprotéine B (Apo B), conviennent comme médicament en prévention ou traitement d'affections ou d'états résultant de niveaux élevés d'ApoB circulant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)