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Machine translation
1. (WO2002028437) REGIOSELECTIVE LIQUID PHASE PEGYLATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/028437    International Application No.:    PCT/EP2001/011427
Publication Date: 11.04.2002 International Filing Date: 03.10.2001
Chapter 2 Demand Filed:    02.05.2002    
IPC:
A61K 47/48 (2006.01)
Applicants: ARES TRADING S.A. [CH/CH]; Château de Vaumarcus CH-2028 Vaumarcus (CH) (For All Designated States Except US).
PIQUET, Gilles [IT/IT]; (IT) (For US Only).
BARBERO, Luca [IT/IT]; (IT) (For US Only).
TRAVERSA, Silvio [IT/IT]; (IT) (For US Only).
GATTI, Monica [IT/IT]; (IT) (For US Only)
Inventors: PIQUET, Gilles; (IT).
BARBERO, Luca; (IT).
TRAVERSA, Silvio; (IT).
GATTI, Monica; (IT)
Agent: SERONO INTERNATIONAL S.A.; Intellectual Property 12, chemin des Aulx CH-1228 Plan-les-Ouates (CH)
Priority Data:
00121744.7 05.10.2000 EP
Title (EN) REGIOSELECTIVE LIQUID PHASE PEGYLATION
(FR) PEGYLATION STEREOSELECTIVE EN PHASE LIQUIDE
Abstract: front page image
(EN)A method is described for a method for the regioselective liquid-phase pegylation of GRF, which increases the yield of the GRF-PEG conjugate having 1 PEG molecule covalently bound to the e-amino group of Lys?12¿. This method is characterized in that the reaction is carried out in a structuring solvent, such as trifluorethanol.
(FR)La présente invention concerne un procédé de pégylation stéréosélective en phase liquide de GRF, qui accroît le rendement du conjugué GRF-PEG dans lequel une molécule PEG est liée de manière covalente au groupe e-amino de Lys?12¿. Ce procédé se caractérise en ce que la réaction est effectuée dans un solvant structurant, tel que le trifluoréthanol.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)