WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2002027019) METHOD OF PREDICTING THE CLINICAL RESPONSE TO CHEMOTHERAPEUTIC TREATMENT WITH ALKYLATING AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/027019    International Application No.:    PCT/US2001/030881
Publication Date: 04.04.2002 International Filing Date: 01.10.2001
Chapter 2 Demand Filed:    29.04.2002    
IPC:
C12Q 1/48 (2006.01), C12Q 1/68 (2006.01), G01N 33/50 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE [US/US]; 111 Market Place, Suite 906, Baltimore, MD 21202 (US) (For All Designated States Except US).
BAYLIN, Stephen, B. [US/US]; (US) (For US Only).
HERMAN, James, G. [US/US]; (US) (For US Only).
ESTELLER, Manel [ES/ES]; (ES) (For US Only)
Inventors: BAYLIN, Stephen, B.; (US).
HERMAN, James, G.; (US).
ESTELLER, Manel; (ES)
Agent: HAILE, Lisa, A.; Gary Cary Ware & Friedenrich LLP, Suite 1100, 4365 Executive Drive, San Diego, CA 92121-2133 (US)
Priority Data:
60/236,760 29.09.2000 US
Title (EN) METHOD OF PREDICTING THE CLINICAL RESPONSE TO CHEMOTHERAPEUTIC TREATMENT WITH ALKYLATING AGENTS
(FR) METHODE DE PREDICTION DE LA REACTION CLINIQUE A UN TRAITEMENT CHIMIOTHERAPEUTIQUE AVEC DES AGENTS ALKYLANTS
Abstract: front page image
(EN)The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain types of chemotherapeutic agents. Aklylating agents, used for the treatment of certain types of tumors including tumors of the nervous system and lymph system, are efficacious agents when the damage they do to tumor cell DNA is not repaired by cellular DNA repair mechanisms. The present invention provides a method for determining the activity of a gene encoding a DNA repair enzyme, thus providing a prediction of the clinical response to alkylating agents. Figure (1) shows the overall survival among subjects with gliomas treated carmustine, and the time of progression of disease according to the methylation status of the MGMT promoter.
(FR)L'invention concerne des méthodes liées au traitement chimiothérapeutique d'un trouble de la prolifération cellulaire. L'invention concerne notamment une méthode permettant de prédire la réaction clinique à certains types d'agents chimiothérapeutiques. Les agents alkylants, utilisés pour le traitement de certains types de tumeurs parmi lesquelles des tumeurs du système nerveux et du système lymphatique, sont des agents efficaces lorsque les dommages qu'ils causent à l'ADN de cellules tumorales ne sont pas réparés par les mécanismes de réparation de l'ADN cellulaire. L'invention concerne en outre une méthode permettant de déterminer l'activité d'un gène codant pour une enzyme de réparation de l'ADN, fournissant ainsi une prédiction de la réaction clinique à des agents alkylants.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)