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1. (WO2002026962) METHOD OF EXAMINING ALLERGIC DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/026962    International Application No.:    PCT/JP2001/008247
Publication Date: 04.04.2002 International Filing Date: 21.09.2001
Chapter 2 Demand Filed:    01.03.2002    
IPC:
C07K 14/47 (2006.01), C12Q 1/68 (2006.01)
Applicants: GENOX RESEARCH, INC. [JP/JP]; 5-1-3, Tokodai Tsukuba-shi, Ibaraki 300-2635 (JP) (For All Designated States Except US).
JAPAN as represented by GENERAL DIRECTOR OF AGENCY OF NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT [JP/JP]; 10-1, Okura 2-chome Setagaya-ku, Tokyo 157-8535 (JP) (For All Designated States Except US).
SUGITA, Yuji [JP/JP]; (JP) (For US Only).
HASHIDA, Ryoichi [JP/JP]; (JP) (For US Only).
OGAWA, Kaoru [JP/JP]; (JP) (For US Only).
FUJISHIMA, Tomoko [JP/JP]; (JP) (For US Only).
NAGASU, Takeshi [JP/JP]; (JP) (For US Only).
SAITO, Hirohisa [JP/JP]; (JP) (For US Only)
Inventors: SUGITA, Yuji; (JP).
HASHIDA, Ryoichi; (JP).
OGAWA, Kaoru; (JP).
FUJISHIMA, Tomoko; (JP).
NAGASU, Takeshi; (JP).
SAITO, Hirohisa; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki 300-0847 (JP)
Priority Data:
2000-293021 26.09.2000 JP
Title (EN) METHOD OF EXAMINING ALLERGIC DISEASE
(FR) PROCEDE D'EXAMEN DE MALADIES ALLERGIQUES
Abstract: front page image
(EN)By using the differential display method, it is attempted to search for genes showing a difference in expression in eosinophils collected from patients with atopic dermatitis in the increment stage and in the remission stage. As a result, genes '2259-01', '2298-09', '2255-02', '2292-04' and '2182-02', each showing a significant increase in expression in eosinophils of patients in the remission stage, are isolated. It is found out that these genes are usable in examining an allergic disease and screening a candidate compound for a remedy therefor.
(FR)En utilisant la méthode dite 'differential display', on a tenté de rechercher les gènes présentant une différence d'expression dans les éosinophiles recueillis sur des patients souffrant d'une dermatite atopique en phase de croissance et en phase de rémission. On a pu ainsi isoler les gènes '2259-01', '2298-09', '2255-02', '2292-04' et '2182-02', présentant chacun une augmentation importante de l'expression dans les éosinophiles de patients en phase de rémission. On a découvert que ces gènes sont utilisables pour examiner une maladie allergique et pour sélectionner un composé candidat pour un remède contre cette maladie.
Designated States: CA, JP, US.
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)