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Machine translation
1. (WO2002026731) QUATERNARY AMIDINO BASED INHIBITORS OF FACTOR XA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/026731    International Application No.:    PCT/US2001/030314
Publication Date: 04.04.2002 International Filing Date: 01.10.2001
Chapter 2 Demand Filed:    29.04.2002    
IPC:
C07D 213/75 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01)
Applicants: MILLENIUM PHARMACEUTICALS, INC. [US/US]; 256 East Grand Avenue, South San Francisco, CA 94080 (US) (For All Designated States Except US).
ZHU, Bing-Yan [CA/US]; (US) (For US Only).
HUANG, Wenrong [CN/US]; (US) (For US Only).
ZHANG, Penglie [CN/US]; (US) (For US Only).
JIA, Zhaozhong, Jon [CN/US]; (US) (For US Only).
BAO, Liang [CN/US]; (US) (For US Only).
WU, Yanhong [CN/US]; (US) (For US Only).
SCARBOROUGH, Robert, M. [US/US]; (US) (For US Only)
Inventors: ZHU, Bing-Yan; (US).
HUANG, Wenrong; (US).
ZHANG, Penglie; (US).
JIA, Zhaozhong, Jon; (US).
BAO, Liang; (US).
WU, Yanhong; (US).
SCARBOROUGH, Robert, M.; (US)
Agent: LEE, Christine, S.; Morgan, Lewis & Bockius LLP, 1111 Pennsylvania Avenue, NW, Washington, DC 20004 (US).
WEIMAR, Elizabeth, C.; Morgan, Lewis & Bockius LLP, 1111 Pennsylvania Avenue, N.W., Washington, DC 20004 (US)
Priority Data:
60/236,385 29.09.2000 US
Title (EN) QUATERNARY AMIDINO BASED INHIBITORS OF FACTOR XA
(FR) INHIBITEURS DU FACTEUR XA A BASE D'AMIDINOS QUATERNAIRES
Abstract: front page image
(EN)Novel quaternary amidino-containing compounds of the general formulae (I), (II), (III), (IV), (V) and (VI): including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
(FR)L'invention porte sur de nouveaux composés contenant des amidinos quaternaires de formule générale (I), (II), (III), (IV), (V) et (VI) ou leurs isomères, sels, hydrates, solvates et prodrogues, pharmacocompatibles, présentant une activité contre le facteur Xa des mammifères, et sur des préparations contenant lesdits composés. Ces composés et préparations s'utilisent in vitro ou in vivo pour prévenir et traiter chez les mammifères des états caractérisés par des thromboses indésirées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)