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1. WO2002026703 - CARBAMIC ACID COMPOUNDS COMPRISING AN ETHER LINKAGE AS HDAC INHIBITORS

Publication Number WO/2002/026703
Publication Date 04.04.2002
International Application No. PCT/GB2001/004327
International Filing Date 27.09.2001
Chapter 2 Demand Filed 26.04.2002
IPC
C07C 259/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
259Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
04without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
06having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 323/60 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
CPC
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 259/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
259Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
04without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
06having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 323/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Applicants
  • PROLIFIX LIMITED [GB]/[GB] (AllExceptUS)
  • WATKINS, Clare, J. [GB]/[GB] (UsOnly)
  • ROMERO MARTIN, Maria Rosario [ES]/[GB] (UsOnly)
  • FINN, Paul, W. [GB]/[GB] (UsOnly)
  • KALVINSH, Ivars [LV]/[LV] (UsOnly)
  • LOZA, Einars [LV]/[LV] (UsOnly)
  • LOLYA, Daina [LV]/[LV] (UsOnly)
  • STARCHENKOV, Igor [--]/[LV] (UsOnly)
  • BOKALDERE, Rasma, Melita [LV]/[LV] (UsOnly)
  • SEMENIKHINA, Valentina [--]/[LV] (UsOnly)
  • HARRIS, C., John [GB]/[GB] (UsOnly)
  • DUFFY, James, E., S. [GB]/[GB] (UsOnly)
Inventors
  • WATKINS, Clare, J.
  • ROMERO MARTIN, Maria Rosario
  • FINN, Paul, W.
  • KALVINSH, Ivars
  • LOZA, Einars
  • LOLYA, Daina
  • STARCHENKOV, Igor
  • BOKALDERE, Rasma, Melita
  • SEMENIKHINA, Valentina
  • HARRIS, C., John
  • DUFFY, James, E., S.
Agents
  • ARMITAGE, Ian, M.
Priority Data
0023983.029.09.2000GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CARBAMIC ACID COMPOUNDS COMPRISING AN ETHER LINKAGE AS HDAC INHIBITORS
(FR) COMPOSES D'ACIDE CARBAMIQUE COMPRENANT UNE LIAISON ETHER ET UTILES EN TANT QU'INHIBITEURS DE HDAC
Abstract
(EN) This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula(I) wherein: A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is an amide linkage selected from: -NR1C(=O)- and -C(=O)NR1-; R1 is an amido substituent; X is an ether heteroatom, and is -O- or -S-; and, R2 and R3 are each independently an ether group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
(FR) L'invention concerne certains composés d'acide carbamique, actifs, inhibant l'activité de HDAC (histone désacétylase) et possédant la formule suivante (I) dans laquelle A représente un groupe aryle, Q1 représente une liaison covalente ou un groupe leader aryle, J représente une liaison amide choisie entre -NR1C(=O)- et -C(=O)NR1-, R1 représente un substituant amido, X représente un hétéroatome d'éther et représente -O- ou -S-, et R2 et R3 représentent chacun indépendamment un groupe éther. L'invention concerne également des sels, solvates, amides, esters, éthers, formes chimiquement protégées, et promédicaments de ces composés, et elle concerne encore des compositions pharmaceutiques comprenant de tels composés, ainsi que l'utilisation de ces composés et compositions, à la fois in vitro et in vivo, pour inhiber HDAC et, par exemple, pour inhiber des désordres prolifératifs, tels que le cancer et le psoriasis.
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