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1. (WO2002026265) PEGYLATED INTERLEUKIN-10
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/026265    International Application No.:    PCT/US2001/042431
Publication Date: 04.04.2002 International Filing Date: 28.09.2001
Chapter 2 Demand Filed:    22.02.2002    
IPC:
A61K 47/48 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; Patent Department - K-6-1 1990 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 (US)
Inventors: LEE, Seoju; (US).
WYLIE, David, C.; (US).
CANNON-CARLSON, Susan, V.; (US)
Agent: SCHRAM, David, B.; Schering-Plough Corporation Patent Department - K-6-1 1990 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 (US).
THAMPOE, Immac, J.; Schering-plough Corporation Patent Department, K-6-1 1990 2000 Galloping Hill Road Kenilworth, Nj New Jersey 07033-0530 (US)
Priority Data:
60/236,596 29.09.2000 US
Title (EN) PEGYLATED INTERLEUKIN-10
(FR) INTERLEUKINE 10 PEGYLEE
Abstract: front page image
(EN)Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
(FR)L'invention concerne l'interleukine 10 (IL-10) conjuguée via un liant à une ou plusieurs molécules de polyéthylène glycol (PEG) dans un seul résidu d'aminoacide d'IL-10, ainsi que sa méthode de préparation. Cette méthode permet d'obtenir une IL-10 mono-pégylée, qui maintient l'activité de IL-10, la pégylation étant sélective pour le N-terminal sur une sous-unité de IL-10 avec peu ou pas de formation de IL-10 monomère. L'invention concerne enfin une population sensiblement homogène de mono-PEG-IL-10.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, HR, HU, ID, IL, IN, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LU, LV, MA, MD, MG, MK, MN, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UZ, VN, YU, ZA.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)