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1. (WO2002026241) POLYMERIC MICELLE CONTAINING CISPLATIN ENCLOSED THEREIN AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/026241    International Application No.:    PCT/JP2001/008337
Publication Date: 04.04.2002 International Filing Date: 26.09.2001
Chapter 2 Demand Filed:    26.09.2001    
IPC:
A61K 9/107 (2006.01), A61K 9/51 (2006.01), A61K 33/24 (2006.01), A61K 38/00 (2006.01), A61K 47/48 (2006.01), C08G 69/40 (2006.01), C08G 69/44 (2006.01)
Applicants: CENTER FOR ADVANCED SCIENCE AND TECHNOLOGY INCUBATION, LTD. [JP/JP]; 6th Fl., Shin-Marunouchi Bldg. 5-1, Marunouchi 1-chome Chiyoda-ku, Tokyo 100-0005 (JP) (For All Designated States Except US).
KATAOKA, Kazunori [JP/JP]; (JP) (For US Only).
NISHIYAMA, Nobuhiro [JP/JP]; (JP) (For US Only).
YOKOYAMA, Masayuki [JP/JP]; (JP) (For US Only).
OKANO, Teruo [JP/JP]; (JP) (For US Only)
Inventors: KATAOKA, Kazunori; (JP).
NISHIYAMA, Nobuhiro; (JP).
YOKOYAMA, Masayuki; (JP).
OKANO, Teruo; (JP)
Agent: ODAJIMA, Heikichi; Odajima Patent Office Nippon Jitensya Bldg. 9-15, Akasaka 1-chome Minato-ku, Tokyo 107-0052 (JP)
Priority Data:
2000-292218 26.09.2000 JP
Title (EN) POLYMERIC MICELLE CONTAINING CISPLATIN ENCLOSED THEREIN AND USE THEREOF
(FR) MICELLE POLYMERE RENFERMANT DU CISPLATINE ET UTILISATION
Abstract: front page image
(EN)A complex comprising cisplatin and a poly(ethylene glycol)/poly(glutamic acid) block copolymer, wherein the cisplatin is enclosed in the copolymer through ligand displacement in which a carboxyl anion of the copolymer is replaced with a chlorine ion of the cisplatin. This complex can give a medicine reduced in toxicity and usable by a new method of administration.
(FR)L'invention concerne un complexe contenant du cisplatine et un copolymère séquencé de poly(éthylène glycol)/poly(acide glutamique), le cisplatine étant intégré dans le copolymère par déplacement de ligand au cours duquel un anion carboxyl du copolymère est remplacé par un ion chlore du cisplatine. Ledit complexe peut servir d'agent pharmaceutique de toxicité réduite et peut être administré selon un nouveau procédé.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)