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1. (WO2002026236) TUMOR CELL KILLING BY CELL CYCLE CHECKPOINT ABROGATION COMBINED WITH INHIBITION OF THE 'CLASSICAL' MITOGEN ACTIVATED PROTEIN (MAP) KINASE PATHWAY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/026236    International Application No.:    PCT/US2001/030508
Publication Date: 04.04.2002 International Filing Date: 28.09.2001
Chapter 2 Demand Filed:    13.03.2002    
IPC:
A61K 31/52 (2006.01), A61K 31/522 (2006.01), A61K 31/535 (2006.01), A61K 31/55 (2006.01), A61K 41/00 (2006.01)
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY [US/US]; 1101 East Marshall Street, Richmond, VA 21298 (US) (For All Designated States Except US).
DENT, Paul [US/US]; (US) (For US Only).
GRANT, Steven [US/US]; (US) (For US Only).
MCKINSTRY, Robert [US/US]; (US) (For US Only).
DAI, Yum [CN/US]; (US) (For US Only)
Inventors: DENT, Paul; (US).
GRANT, Steven; (US).
MCKINSTRY, Robert; (US).
DAI, Yum; (US)
Agent: WHITHAM, Michael, E.; Whitham, Curtis & Christofferson, P.C., Suite 340, 11491 Sunset Hills Road, Reston, VA 20190 (US)
Priority Data:
60/235,938 28.09.2000 US
Title (EN) TUMOR CELL KILLING BY CELL CYCLE CHECKPOINT ABROGATION COMBINED WITH INHIBITION OF THE 'CLASSICAL' MITOGEN ACTIVATED PROTEIN (MAP) KINASE PATHWAY
(FR) ELIMINATION DE CELLULES TUMORALES PAR SUPPRESSION DU POINT DE CONTROLE DE CYCLE COMBINE A L'INHIBITION DU TRAJET CLASSIQUE DE PROTEINE KINASE ACTIVEE PAR MITOGENE
Abstract: front page image
(EN)The present invention provides a method for treating cancer by promoting apoptosis and reducing clonogenic survival of cancer cells. The method encompasses co-administering 1) a cell cycle checkpoint abrogation agent (for example, UCN-01 or caffeine) and 2) an inhibitor of a compensatory cytoprotective pathway, such as an agent that inhibits the MEK 1/2 pathway (e.g. PD98059, U0126, or PD184352) or an agent that inhibits the PI 3 pathway (e.g. LY294002 or wortmanin). In addition, because the co-administration step also radiosensitizes cancer cells, the method additionally encompasses the administration of radiation to further reduce clonogenic survival of cancer cells. The method promotes apoptosis and reduces clonogenic survival in many types of cancer cells, including leukemia cells, prostate cancer cells, breast cancer cells, myeloma cells, and lymphoma cells.
(FR)La présente invention concerne une technique de traitement du cancer qui consiste à favoriser l'apoptose et à réduire la survie clonogénique des cellules cancéreuses. Cette technique consiste à administrer (1) un agent de suppression de point de contrôle de cycle cellulaire (par exemple UCN-01 ou de la caféine) et (2) un inhibiteur de trajet cytoprotecteur compensateur, tel qu'un agent qui inhibe le trajet MEK 1/2 (par exemple PD98059, U0126 ou PD184352) ou tel qu'un agent qui inhibe le trajet PI 3 (par exemple LY294002 ou de la wortmanine). Par ailleurs, du fait que cette co-administration radiosensibilise les cellules cancéreuses, cette technique consiste, en outre à administrer des rayons de façon à réduire encore la survie clonogénique des cellules cancéreuses. Cette technique favorise l'apoptose et réduit la survie clonogénique de nombreux types de cellules cancéreuses, notamment celles de la leucémie, du cancer de la prostate, du cancer du sein, les cellules de myélome et de lymphome.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)